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Titolo:
Acute, nongenomic vasodilatory action of estradiol is attenuated by chronic estradiol treatment
Autore:
Kakucs, R; Varbiro, S; Nadasy, GL; Monos, E; Szekacs, B;
Indirizzi:
Semmelweis Univ Med, Inst Phys 2, Dept Clin Res, H-1082 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1082 es, H-1082 Budapest, Hungary Semmelweis Univ Med, Inst Phys 2, Dept Med 2, H-1082 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1082 2, H-1082 Budapest, Hungary
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 226, anno: 2001,
pagine: 538 - 542
SICI:
1535-3702(200106)226:6<538:ANVAOE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; CORONARY-ARTERY; BLOOD-FLOW; ESTROGEN; 17-BETA-ESTRADIOL; PROGESTERONE; RELAXATION; RESPONSES; THERAPY;
Keywords:
small artery; vasodilation; estradiol; estradiol replacement; nongenomic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kakucs, R Semmelweis Univ Med, Inst Phys 2, Dept Clin Res, Uli Foi Ut 78-A, H-1082 Budapest, Hungary Semmelweis Univ Med Uli Foi Ut 78-A Budapest Hungary H-1082 ary
Citazione:
R. Kakucs et al., "Acute, nongenomic vasodilatory action of estradiol is attenuated by chronic estradiol treatment", EXP BIOL ME, 226(6), 2001, pp. 538-542

Abstract

Deficiency of estradiol or chronic estrogen treatment may alter the responses to this hormone in many tissues. A possible interaction between the acute nongenomic and the chronic effects of estradiol on microvessels have notbeen investigated yet. In the present study we have investigated whether acute in vitro vasodilatory action of estradiol on a small artery is alteredby chronic estradiol pretreatment, Female rats were surgically ovariectomized and subjected to either estradiol replacement therapy (estradiol propionate, 450 mug/kg/week) or vehicle administration for 5 weeks, Cylindrical segments of the saphenous artery were studied using videocomputerized microarteriography in vitro, Estradiol, in concentrations of 10(-6) to 10(-4) M relaxed norepinephrine precontracted vessel segments in a dose-dependent manner. Magnitude of relaxation observed in arteries of estradiol replaced animals was significantly smaller at all concentrations than that of nonreplaced ovariectomized rats; maximal relaxation in the control ovariectomized group was 64.5% +/- 3.6%, while it was 34.3% +/- 4.2% only in the ovariectomized and estradiol replaced group (P < 0.001), Comparison of acute relaxations in response to papaverine and nifedipine failed to prove a reduced activity of the general relaxation machinery in estradiol replaced animals. We conclude that chronic estradiol replacement can downregulate the acute nongenomic vasorelaxation effect of this hormone in small arteries of ovariectomized rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:28:27