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Titolo:
Mesenchymal stem cells
Autore:
Minguell, JJ; Erices, A; Conget, P;
Indirizzi:
Univ Chile, INTA, Unidad Biol Celular, Santiago 11, Chile Univ Chile Santiago Chile 11 TA, Unidad Biol Celular, Santiago 11, Chile Clin Las Condes, Lab Transplante Medula Osea, Santiago, Chile Clin Las Condes Santiago Chile Transplante Medula Osea, Santiago, Chile
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 226, anno: 2001,
pagine: 507 - 520
SICI:
1535-3702(200106)226:6<507:MSC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BONE-MARROW; HEMATOPOIETIC PROGENITOR CELLS; COLONY-STIMULATING FACTOR; FULL-THICKNESS DEFECTS; BREAST-CANCER PATIENTS; STROMAL CELLS; IN-VITRO; GROWTH-FACTOR; MORPHOGENETIC PROTEIN-2; PERIPHERAL-BLOOD;
Keywords:
mesenchymal stem cells; marrow stromal cells; uncommitted mesenchymal progenitors; human mesenchymal stem cells; characteristics mesenchymal progenitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Minguell, JJ Univ Chile, INTA, Unidad Biol Celular, Casilla 183, Santiago 11, Chile Univ Chile Casilla 183 Santiago Chile 11 Santiago 11, Chile
Citazione:
J.J. Minguell et al., "Mesenchymal stem cells", EXP BIOL ME, 226(6), 2001, pp. 507-520

Abstract

Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded and induced, either in vitro or in vivo, to terminally differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural cells, and hematopoietic-supporting stroma. The multipotential of these cells, their easy isolation and culture, as well as theirhigh ex vivo expansive potential make these cells an attractive therapeutic tool. In this work we will review the information dealing with the biology of mesenchymal progenitors as it has been revealed mainly by ex vivo studies performed with bone marrow-derived cells. The discussed topics include,among others, characteristics of mesenchymal progenitors, evidence for theexistence of a vast repertoire of uncommitted and committed progenitors both in the bone marrow and in mesenchymal tissues, a diagram for their proliferative hierarchy, and comments on mobilization, microenvironment, and clinical use of mesenchymal progenitors. Despite the enormous data available at molecular and cellular levels, it is evident that a number of fundamentalquestions still need to be resolved before mesenchymal progenitors can be used for safe and effective clinical applications in the context of both cell and gene therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:43:15