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Titolo:
Omega-3 polyunsaturated fatty acids and skeletal health
Autore:
Watkins, BA; Li, Y; Lippman, HE; Seifert, MF;
Indirizzi:
Purdue Univ, Dept Food Sci, Lipid Chem & Mol Biol Lab, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Biol Lab, W Lafayette, IN 47907 USA Indiana Univ Purdue Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN46202 USA Indiana Univ Purdue Univ Indianapolis IN USA 46202 ianapolis, IN46202 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 226, anno: 2001,
pagine: 485 - 497
SICI:
1535-3702(200106)226:6<485:OPFAAS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-E-RECEPTOR; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-I; OSTEOCLAST DIFFERENTIATION FACTOR; BONE-MINERAL DENSITY; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; RHEUMATOID-ARTHRITIS PATIENTS; FISH OIL SUPPLEMENTATION; OSTEOBLAST-LIKE CELLS; MESSENGER-RNA LEVELS;
Keywords:
omega-3 fatty acids; bone; prostaglandins; osteoporosis; phytoestrogens;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Watkins, BA Purdue Univ, Dept Food Sci, Lipid Chem & Mol Biol Lab, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Lafayette, IN 47907 USA
Citazione:
B.A. Watkins et al., "Omega-3 polyunsaturated fatty acids and skeletal health", EXP BIOL ME, 226(6), 2001, pp. 485-497

Abstract

This minireview on skeletal biology describes the actions of prostaglandins and cytokines involved in the local regulation of bone metabolism, it documents the role of lipids in bone biology, and it presents relationships between fatty acids and other factors that impact skeletal metabolism. The data presented herein show consistent and reproducible beneficial effects of omega-3 (n-3) fatty acids on bone metabolism and bone/joint diseases. Polyunsaturated fatty acids modulate eicosanoid biosynthesis in numerous tissuesand cell types, alter signal transduction, and influence gene expression. These effects have not been explored in the skeletal system. Future research on n-3 fatty acids in bone biology should focus on the following two aspects. First, the further elucidation of how n-3 fatty acids alter biochemical and molecular processes involved in bone modeling and bone cell differentiation, and second, the evaluation of the potential pharmaceutical applications of these nutraceutical fatty acids in maintaining bone mineral status and controlling inflammatory bone/joint diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:23:06