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Titolo:
Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines
Autore:
Veldhuizen, RAW; Slutsky, AS; Joseph, M; McCaig, L;
Indirizzi:
Univ Western Ontario, Lawson Res Inst, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Med, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Physiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada St Josephs Hlth Ctr, Dept Pathol, London, ON, Canada St Josephs Hlth Ctr London ON Canada tr, Dept Pathol, London, ON, Canada Univ Toronto, Mt Sinai Hosp, Dept Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 t Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Dept Surg, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Surg, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 17, anno: 2001,
pagine: 488 - 494
SICI:
0903-1936(200103)17:3<488:EOMVOI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; ISOLATED RAT LUNG; PULMONARY SURFACTANT; AGGREGATE CONVERSION; TIDAL VOLUME; INJURY; SUBFRACTIONS; METABOLISM; MORTALITY;
Keywords:
ARDS; lung injury; mechanical ventilation; surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Veldhuizen, RAW Univ Western Ontario, Lawson Res Inst, Room G454,268 Grosvenor St, London,ON N6A 4V2, Canada Univ Western Ontario Room G454,268 Grosvenor St London ON Canada N6A 4V2
Citazione:
R.A.W. Veldhuizen et al., "Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines", EUR RESP J, 17(3), 2001, pp. 488-494

Abstract

Mechanical ventilation of the lung is an essential but potentially harmfultherapeutic intervention for patients with acute respiratory distress syndrome. The objective of the current study was to establish and characterize an isolated mouse lung model to study the harmful effects of mechanical ventilation. Lungs were isolated from BalbC mice and randomized to either a nonventilated group, a conventionally ventilated group (tidal volume 7 mL.kg(-1), 4 cmpositive end-expiratory pressure (PEEP)) or an injuriously ventilated group (20 mL.kg(-1), 0 cm PEEP). Lungs were subsequently analysed for lung compliance, morphology, surfactant composition and inflammatory cytokines. Injurious ventilation resulted in significant lung dysfunction, which mas associated with a significant increase in pulmonary surfactant, and surfactant small aggregates compared to the other two groups. Injurious ventilation also led to a significantly increased concentration of interleukin-6 and tumour necrosis factor-a in the lavage. It was concluded that the injurious effects of mechanical ventilation can effectively be studied in isolated mouse lung, which offers the potential of studying genetically altered animals. It mas also concluded that in this model, the lung injury is, in part, mediated by the surfactant system and the release of inflammatory mediators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:26:42