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Titolo:
Genetic deficiency of alpha(1)-PI in mice influences lung responses to bleomycin
Autore:
Cavarra, E; Martorana, PA; Bartalesi, B; Fineschi, S; Gambelli, F; Lucattelli, M; Ortiz, L; Lungarella, G;
Indirizzi:
Univ Siena, Dept Physiopathol & Expt Med, I-53100 Siena, Italy Univ SienaSiena Italy I-53100 iopathol & Expt Med, I-53100 Siena, Italy Tulane Univ, Med Ctr, New Orleans, LA 70118 USA Tulane Univ New Orleans LA USA 70118 , Med Ctr, New Orleans, LA 70118 USA
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 17, anno: 2001,
pagine: 474 - 480
SICI:
0903-1936(200103)17:3<474:GDOAIM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; HUMAN NEUTROPHIL ELASTASE; NECROSIS-FACTOR-ALPHA; EMPHYSEMA; INHIBITOR; INFLAMMATION; HAMSTERS; MOUSE; PATHOGENESIS; DISEASE;
Keywords:
antiproteases; collagen; cytokines; elastin; mouse intrastrain variability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Lungarella, G Univ Siena, Dept Physiopathol & Expt Med, Via Aldo Moro, I-53100 Siena, Italy Univ Siena Via Aldo Moro Siena Italy I-53100 0 Siena, Italy
Citazione:
E. Cavarra et al., "Genetic deficiency of alpha(1)-PI in mice influences lung responses to bleomycin", EUR RESP J, 17(3), 2001, pp. 474-480

Abstract

It has recently been suggested that proteinase inhibitors modulate the fibrotic response in the lung. This study investigated the development of bleomycin-induced pulmonary changes in pallid mice, deficient in serum al-proteinase inhibitor, and with a lower elastase inhibitory capacity, and in congenic C57Bl/6J mice. Male pallid and C57Bl/6J mice received a single intratracheal instillationof either saline or bleomycin. The investigation was carried out by means of biochemical, morphological and morphometrical methods. In both strains, 21 and 72 h after bleomycin, the lungs showed foci of inflammatory cell infiltration associated with emphysema. Fibrosis developed,vith time after bleomycin. At 14 days fibrosis affected 23.46 +/- 9.48% (mean +/- SD) and 40.62 +/- 13.33% (p < 0.01) of the lungs of C57Bl/6J and pallid mice, respectively. Emphysema affected 3.68 +/-3.11% and 12.57 +/-4.13% (p <0.01) of lung in C57Bl/6J and pallid mice, respectively. In C57Bl/6J mice bleomycin increased lung hydroxyproline content by 34% and desmosine content by 44% (p <0.01 for both). In pallid mice these increases mere only 21% (p <0.01) and 6%, which may reflect parenchymal loss. Thus, the lung destructive response (emphysema) and the subsequent proliferative reaction (fibrosis) to bleomycin are potentiated in alpha (1)-proteinase inhibitor deficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:55:15