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Titolo:
Delta(9)-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study
Autore:
Acquas, E; Pisanu, A; Marrocu, P; Goldberg, SR; Di Chiara, G;
Indirizzi:
Univ Cagliari, Dept Toxicol, I-09126 Cagliari, Italy Univ Cagliari Cagliari Italy I-09126 pt Toxicol, I-09126 Cagliari, Italy CNR, Ctr Neuropharmacol, I-09126 Cagliari, Italy CNR Cagliari Italy I-09126 , Ctr Neuropharmacol, I-09126 Cagliari, Italy NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 Neurosci Branch, NIH, Baltimore, MD 21224 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 419, anno: 2001,
pagine: 155 - 161
SICI:
0014-2999(20010511)419:2-3<155:DECAHA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANNABINOID RECEPTOR AGONIST; MEDIAL-PREFRONTAL CORTEX; FREELY MOVING RATS; MEMORY; DELTA-9-TETRAHYDROCANNABINOL; ANANDAMIDE; ACTIVATION; MECHANISM;
Keywords:
acetylcholine; hippocampus; Delta(9)-tetrahydrocannabinol; microdialysis, in vivo; cortex, prefrontal; SR 141716A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Di Chiara, G Univ Cagliari, Dept Toxicol, Via le A Diaz 182, I-09126 Cagliari, Italy Univ Cagliari Via le A Diaz 182 Cagliari Italy I-09126 Italy
Citazione:
E. Acquas et al., "Delta(9)-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study", EUR J PHARM, 419(2-3), 2001, pp. 155-161

Abstract

The intravenous administration of synthetic cannabinoid agonists was recently shown to dose dependently increase acetylcholine release from the rat prefrontal cortex and hippocampus (Eur. J. Pharmacol. 401 (2000) 179]. We report here that the active ingredient of cannabis preparations, Delta (9)-tetrahydrocannabinol, administered at 10, 37.5, 75 and 150 mug/kg, dose dependently stimulated acetylcholine release from rat prefrontal cortex and hippocampus estimated by means of in vivo brain microdialysis with vertical concentric probes. At these doses, Delta (9)-tetrahydrocannabinol induced behavioural stimulation. The administration of the CB1 receptor antagonist, ((N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidie)HCl) SR 141716A (200 mug/kg i.p.) significantly reduced the effect of Delta (9)-tetrahydrocannabinol (75 mug/kg i.v.) on acetylcholine release from rat prefrontal cortex and hippocampus. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:27:07