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Titolo:
Amphetamine and cocaine induce different patterns of c-fos mRNA expressionin the striatum and subthalamic nucleus depending on environmental context
Autore:
Uslaner, J; Badiani, A; Norton, CS; Day, HEW; Watson, SJ; Akil, H; Robinson, TE;
Indirizzi:
Univ Michigan, Dept Psychol, Biopsychol Programk, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ol Programk, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychol, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA Univ Michigan, Med Ctr, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA UnivMichigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 13, anno: 2001,
pagine: 1977 - 1983
SICI:
0953-816X(200105)13:10<1977:AACIDP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENE; MESSENGER-RNA EXPRESSION; DOPAMINE D-1 RECEPTORS; RAT STRIATUM; BASAL GANGLIA; BEHAVIORAL SENSITIZATION; CORTICAL STIMULATION; SUBSTANTIA-NIGRA; PSYCHOMOTOR STIMULANTS; FUNCTIONAL-ANATOMY;
Keywords:
caudate; c-fos; environmental context; immediate early genes; novelty; rat; striatum; subthalamic nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, TE Univ Michigan, Dept Psychol, Biopsychol Programk, East Hall,525 E Univ St,Ann Arbor, MI 48109 USA Univ Michigan East Hall,525 E Univ St Ann Arbor MI USA 48109
Citazione:
J. Uslaner et al., "Amphetamine and cocaine induce different patterns of c-fos mRNA expressionin the striatum and subthalamic nucleus depending on environmental context", EUR J NEURO, 13(10), 2001, pp. 1977-1983

Abstract

In the dorsal striatum, there are two major populations of medium spiny projection neurons. One population is positive for dynorphin mRNA (DYN+), andthese cells project preferentially to the substantia nigra, forming the so-called 'direct pathway'. A second population is positive for enkephalin mRNA (ENK+), and these cells influence the substantia nigra indirectly, via the globus pallidus and subthalamic nucleus. Psychostimulant drugs, such as amphetamine and cocaine, are reported to induce immediate early genes (IEGs) in only one subpopulation of dorsal striatal projection neurons, DYN+ cells. However, this apparent selectivity appears to be a function of environmental context. We found that when given in the animal's home cage, amphetamine and cocaine increased expression of the IEG, c-fos, almost exclusively in DYN+ cells. However, when given in a novel environment, amphetamine and cocaine increased c-fos mRNA in both DYN+ and ENK+ cells. Furthermore, amphetamine and cocaine increased c-fos mRNA expression in the subthalamic nucleus when administered in the novel environment, but not when given at home. We conclude that the neural circuitry engaged by psychostimulant drugs, and their ability to induce specific patterns of gene expression, are determined by the environmental context in which they are experienced. This may berelated to the ability of environmental novelty to facilitate psychostimulant drug-induced neuroplasticity.

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Documento generato il 25/01/20 alle ore 18:55:35