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Titolo:
Delta(9)-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect
Autore:
Valverde, O; Noble, F; Beslot, F; Dauge, V; Fournie-Zaluski, MC; Roques, BP;
Indirizzi:
UFR Sci Pharmaceut & Biol, Dept Pharmacol Mol & Struct, CNRS,UMR 8600, INSERM,U266, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol Paris France06 U266, F-75270 Paris 06, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 13, anno: 2001,
pagine: 1816 - 1824
SICI:
0953-816X(200105)13:9<1816:DRAFTE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIXED INHIBITOR PRODRUG; RECEPTOR KNOCKOUT MICE; PHARMACOLOGICAL ACTIONS; DEGRADING ENZYMES; PLACE PREFERENCE; DEPENDENT RATS; CANNABINOIDS; DELTA-9-TETRAHYDROCANNABINOL; ANTINOCICEPTION; ABSTINENCE;
Keywords:
behaviour; cannabinoids; dependence; Met-enkephalin; mice; microdialysis; morphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Roques, BP UFR Sci Pharmaceut & Biol, Dept Pharmacol Mol & Struct, CNRS,UMR 8600, INSERM,U266, 4 Ave Observ, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol 4 Ave Observ Paris France 06 France
Citazione:
O. Valverde et al., "Delta(9)-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect", EUR J NEURO, 13(9), 2001, pp. 1816-1824

Abstract

Recent studies have suggested that cannabinoids might initiate the consumption of other highly addictive substances, such as opiates. In this work, we show that acute administration of Delta (9)-tetrahydrocannabinol in mice facilitates the antinociceptive and antidepressant-like responses elicited by the endogenous enkephalins protected from their degradation by RB 101, acomplete inhibitor of enkephalin catabolism. This emphasizes the existenceof a physiological interaction between endogenous opioid and cannabinoid systems. Accordingly, Delta (9)-tetrahydrocannabinol increased the release of Met-enkephalin-like material in the nucleus accumbens of awake and freelymoving rats measured by microdialysis. In addition, this cannabinoid agonist displaced the in vivo [H-3]diprenorphine binding to opioid receptors in total mouse brain. The repetitive pretreatment during 3 weeks of Delta (9)-tetrahydrocannabinol in mice treated chronically with morphine significantly reduces the naloxone-induced withdrawal syndrome. However, this repetitive administration of Delta (9)-tetrahydrocannabinol did not modify or even decrease the rewarding responses produced by morphine in the place preference paradigm. Taken together, these behavioural and biochemical results demonstrate the existence of a direct link between endogenous opioid and cannabinoid systems. However, chronic use of high doses of cannabinoids does not seem to potentiate the psychic dependence to opioids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:25:50