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Titolo:
Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization
Autore:
Florence, SL; Boydston, LA; Hackett, TA; Lachoff, HT; Strata, F; Niblock, MM;
Indirizzi:
Vanderbilt Univ, Dept Psychol, Nashville, TN 37203 USA Vanderbilt Univ Nashville TN USA 37203 t Psychol, Nashville, TN 37203 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 13, anno: 2001,
pagine: 1755 - 1766
SICI:
0953-816X(200105)13:9<1755:SEAPNI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; FUNCTIONAL REORGANIZATION; ADULT MONKEYS; AREA 3B; TACTILE STIMULATION; DISCRIMINATION TASK; RESPONSE PROPERTIES; NEURONAL-ACTIVITY; PARIETAL CORTEX; MACAQUE MONKEYS;
Keywords:
area 3b; macaque monkey; median nerve; plasticity; ventroposterior nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Florence, SL Vanderbilt Univ, Dept Psychol, 301 Wilson Hall, Nashville, TN37203 USA Vanderbilt Univ 301 Wilson Hall Nashville TN USA 37203 03 USA
Citazione:
S.L. Florence et al., "Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization", EUR J NEURO, 13(9), 2001, pp. 1755-1766

Abstract

Sensory perception can be severely degraded after peripheral injuries thatdisrupt the functional organization of the sensory maps in somatosensory cortex, even after nerve regeneration has occurred. Rehabilitation involvingsensory retraining can improve perceptual function, presumably through plasticity mechanisms in the somatosensory processing network. However, virtually nothing is known about the effects of rehabilitation strategies on brain organization, or where the effects are mediated. In this study, five macaque monkeys received months of enriched sensory experience after median nerve cut and repair early in life. Subsequently, the sensory representation of the hand in primary somatosensory cortex was mapped using multiunit microelectrodes. Additionally, the primary somatosensory relay in the thalamus, the ventroposterior nucleus, was studied to determine whether the effects of the enrichment were initiated subcortically or cortically. Age-matched controls included six monkeys with no sensory manipulation after median nervecut and regeneration, and one monkey that had restricted sensory experience after the injury. The most substantial effect of the sensory environment was on receptive field sizes in cortical area 3b. Significantly greater proportions of cortical receptive fields in the enriched monkeys were small and well localized compared to the controls, which showed higher proportions of abnormally large or disorganized fields. The refinements in receptive field size and extent in somatosensory cortex likely provide better resolution in the sensory map and may explain the improved functional outcomes afterrehabilitation in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:20:49