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Titolo:
Respiratory function in adult mice lacking the mu-opioid receptor: role ofdelta-receptors
Autore:
Morin-Surun, MP; Boudinot, E; Dubois, C; Matthes, HW; Kieffer, BL; Denavit-Saubie, M; Champagnat, J; Foutz, AS;
Indirizzi:
CNRS, Inst Neurobiol Alfred Fessard, F-91198 Gif Sur Yvette, France CNRS Gif Sur Yvette France F-91198 ssard, F-91198 Gif Sur Yvette, France Univ Strasbourg 1, Ecol Super Biotechnol Strasbourg, CNRS, UPR 9050, F-67400 Illkirch, France Univ Strasbourg 1 Illkirch France F-67400 9050, F-67400 Illkirch, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 13, anno: 2001,
pagine: 1703 - 1710
SICI:
0953-816X(200105)13:9<1703:RFIAML>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; PRE-BOTZINGER COMPLEX; G-PROTEIN ACTIVATION; NON-NMDA RECEPTORS; KNOCKOUT MICE; BRAIN-STEM; INDUCED ANALGESIA; VENTILATORY ACCLIMATIZATION; POSTNATAL-DEVELOPMENT; KAPPA-RECEPTOR;
Keywords:
brainstem slice; in vitro; in vivo; pre-Botzinger complex; respiratory neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Foutz, AS CNRS, Inst Neurobiol Alfred Fessard, F-91198 Gif Sur Yvette, France CNRS Gif Sur Yvette France F-91198 1198 Gif Sur Yvette, France
Citazione:
M.P. Morin-Surun et al., "Respiratory function in adult mice lacking the mu-opioid receptor: role ofdelta-receptors", EUR J NEURO, 13(9), 2001, pp. 1703-1710

Abstract

Mice lacking the mu -opioid receptor (MOR) provide a unique model to determine whether opioid receptors are functionally interactive. Recent results have shown that respiratory depression produced by delta -opioid receptor agonists is suppressed in mice lacking the mu -opioid receptor. Here we investigated the involvement of mu- and delta -opioid receptors in the control of ventilation and mu/delta receptor interactions in brainstem rhythm-generating structures. Unrestrained MOR-/- and wild-type mice showed similar ventilatory patterns at rest and similar chemosensory responses to hyperoxia (100% O-2), hypoxia (10% O-2) or hypercapnia (5%CO2-95%O-2). Blockade of delta -opioid receptors with naltrindole affected neither the ventilatory patterns nor the ventilatory responses to hypoxia in MOR-/- and wild-type mice. In-vitro, respiratory neurons were recorded in the pre-Botzinger complex of thick brainstem slices of MOR-/- and wild-type young adult mice. Respiratory frequency was not significantly different between these two groups. Thedelta (2) receptor agonist deltorphin II (0.1-1.0 mum) decreased respiratory frequency in both groups whereas doses of the delta (1) receptor agonistenkephalin[D-Pen(2,5)] (0.1-1.0 mum) which were ineffective in wild-type mice significantly decreased respiratory frequency in MOR-/- mice. We conclude that deletion of the mu -opioid receptor gene has no significant effect on ensuing respiratory rhythm generation, ventilatory pattern, or chemosensory control. In MOR-/- mice, the loss of respiratory-depressant effects of delta (2)-opioid receptor agonists previously observed in vivo does not result from a blunted response of delta receptors in brainstem rhythm-generating structures. These structures show an unaltered response to delta (2)-receptor agonists and an augmented response to delta (1)-receptor agonists.

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Documento generato il 26/01/20 alle ore 16:06:24