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Titolo:
Proton pump inhibitors and their drug interactions: an evidence-based approach
Autore:
Gerson, LB; Triadafilopoulos, G;
Indirizzi:
Stanford Univ, Med Ctr, Sch Med, Div Gastroenterol, Stanford, CA 94305 USAStanford Univ Stanford CA USA 94305 Gastroenterol, Stanford, CA 94305 USA
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 611 - 616
SICI:
0954-691X(200105)13:5<611:PPIATD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-MEPHENYTOIN 4'-HYDROXYLATION; STEADY-STATE PHARMACOKINETICS; MULTIPLE-DOSE OMEPRAZOLE; HELICOBACTER-PYLORI; HEALTHY-VOLUNTEERS; POOR METABOLIZERS; PEPTIC-ULCER; NO INFLUENCE; PANTOPRAZOLE; LANSOPRAZOLE;
Keywords:
CYP450; drug interactions; lansoprazole; omeprazole; pantoprazole; proton pump inhibitors; rebeprazole;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Triadafilopoulos, G VA Palo Alto Hlth Care Syst, Gastroenterol Sect 111 GI, 3801 Miranda Ave, Palo Alto, CA 94304 USA VA Palo Alto Hlth Care Syst 3801 Miranda Ave Palo Alto CA USA 94304
Citazione:
L.B. Gerson e G. Triadafilopoulos, "Proton pump inhibitors and their drug interactions: an evidence-based approach", EUR J GASTR, 13(5), 2001, pp. 611-616

Abstract

The proton pump inhibitors (PPIs) are the most effective antisecretory agents used to treat acid-related disorders, As such, they are frequently prescribed for patients who are concurrently using other medications, PPIs may interact with other drugs through numerous mechanisms. The most important include competitive inhibition of hepatic cytochrome P (CYP) 450 enzymes involved in drug metabolism, and alteration of the absorption of other drugs via changes in gastric pH levels, Poor metabolizers, who lack CYP2C19, may be particularly predisposed to drug interactions, Although the potential fordrug interactions is high, few clinically significant interactions have been reported for the PPIs, Nevertheless, caution is indicated when certain drugs are co-prescribed with these agents, The incidence of clinically significant drug interactions increases proportionately with the number of drugstaken and with the age of the patient, The drug interaction with the greatest clinical importance is the reduction in benzodiazepine clearance by omeprazole, Eur J Gastroenterol Hepatol 13:611-616 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:43:22