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Titolo:
Defining gluten refractory enteropathy
Autore:
Biagi, F; Corazza, GR;
Indirizzi:
Univ Pavia, IRCCS, Policlin San Matteo, Gastroenterol Unit, I-27100 Pavia,Italy Univ Pavia Pavia Italy I-27100 , Gastroenterol Unit, I-27100 Pavia,Italy
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 561 - 565
SICI:
0954-691X(200105)13:5<561:DGRE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; CELIAC-DISEASE; INTRAEPITHELIAL LYMPHOCYTES; AUTOIMMUNE ENTEROPATHY; VILLOUS ATROPHY; SPRUE; CYCLOSPORINE; MALABSORPTION; RECOVERY; COLITIS;
Keywords:
coeliac disease; endomysial antibody; gluten-free diet; refractory sprue; small bowel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Biagi, F Univ Pavia, IRCCS, Policlin San Matteo, Gastroenterol Unit, P Golgi 19, I-27100 Pavia, Italy Univ Pavia P Golgi 19 Pavia Italy I-27100 , I-27100 Pavia, Italy
Citazione:
F. Biagi e G.R. Corazza, "Defining gluten refractory enteropathy", EUR J GASTR, 13(5), 2001, pp. 561-565

Abstract

Objective The diagnosis of coeliac disease (CD) is based on the responsiveness of the enteropathy to a gluten-free diet (GFD). This implies that terms such as 'non-responsive CD' and 'refractory CD' are almost paradoxical. In spite of this, these terms are commonly used in the literature, often with different and confusing meanings. Methods On the basis of both a review of the literature and our clinical experience, we propose the following classification, A condition characterized by a refractory enteropathy, not due to lymphoma, ulcerative jejunoileitis or collagenous sprue, but in which gluten sensitivity has been shown previously or could be shown while the patients were on an immunosuppressive therapy should be indicated as refractory CD. Those patients in whom gluten sensitivity can be excluded should be considered to be affected by non-coeliac refractory sprue. Finally, patients in whom the presence of CD cannot be either confirmed or excluded should be considered to be affected by undefined sprue. Results Twenty-four certain refractory patients are described in the literature. The data suggest a diagnosis of refractory CD in 13 patients, non-coeliac refractory sprue in three patients, and undefined sprue in eight patients. Conclusions We define refractory CD as a form of CD that no longer responds to a GFD. Non-coeliac refractory sprue is a condition unrelated to CD. Itcould be either an independent condition or a common end point of different enteropathies. Eur J Gastroenterol Hepatol 1 3:561-565 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:29:35