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Titolo:
Chronic hepatitis C with normal or abnormal aminotransferase levels: is itthe same entity?
Autore:
Herve, S; Savoye, G; Riachi, G; Hellot, MF; Goria, O; Lerebours, E; Colin, R; Ducrotte, P;
Indirizzi:
Rouen Univ Hosp, Digest Tract Res Grp, Rouen, France Rouen Univ Hosp Rouen France Hosp, Digest Tract Res Grp, Rouen, France
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 495 - 500
SICI:
0954-691X(200105)13:5<495:CHCWNO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALANINE TRANSAMINASE-ACTIVITY; BLOOD-DONORS; VIRUS CARRIERS; LIVER-DISEASE; POSITIVE SUBJECTS; NATURAL-HISTORY; ANTI-HCV; FEATURES; SERUM; RNA;
Keywords:
fibrosis; genotype; HCV; hepatitis C; normal ALT level;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Herve, S Hop Charles Nicolle, Grp Rech Appareil Digest, 1 Rue Germont, F-76031 Rouen, France Hop Charles Nicolle 1 Rue Germont Rouen France F-76031 n, France
Citazione:
S. Herve et al., "Chronic hepatitis C with normal or abnormal aminotransferase levels: is itthe same entity?", EUR J GASTR, 13(5), 2001, pp. 495-500

Abstract

Objective The features of hepatitis C virus (HCV) infection with persistently normal serum alanine aminotransferase (ALT) activity levels are not well defined. This study evaluated the characteristics of HCV infection according to the presence or absence of elevated ALT. Methods Demographic data, liver histology and HCV genotype were studied ina group of 80 HCV-RNA-positive subjects with persistently normal ALT (PNALT) (group 1), and compared with a second group of 455 HCV-RNA-positive patients with elevated ALT (group 2). The annual progression of liver fibrosis was also calculated. Results A higher proportion of women was found in group 1: 64% vs 42% in group 2 (P < 0.0002). The HCV genotype 1 was less frequent in group 1:49% vs60% in group 2 and genotype 2 was more frequent: 16% in group 1 vs 4% in group 2 (P < 0.002). Cirrhosis was less frequent in group 1 (4% vs 13% in group 2 (P < 0.0001)). Normal liver was more frequent in group 1: 9% vs 1% ingroup 2 (P < 0.0001). The Knodell score was significantly different between the two groups: 3.2 +/- 0.27 vs 7.15 +/- 0.22 (P < 0.0001). The progression of liver fibrosis was lower in group 1:0.053 +/- 0.14 units/year vs 0.13+/- 0.24 in group 2 (P < 0.007). Conclusion HCV infection with PNALT is associated with less severe histological liver disease and a lower fibrosis progression rate. This suggests that the natural history of HCV infection in these patients is different fromthat in patients with abnormal ALT. Eur J Gastroenterol Hepatol 13:495-500(C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:04:34