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Titolo:
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Autore:
Eiken, HG; Oie, E; Damas, JK; Yndestad, A; Bjerkeli, V; Aass, H; Simonsen, S; Geiran, OR; Tonnessen, T; Christensen, G; Froland, SS; Gullestad, L; Attramadal, H; Aukrust, P;
Indirizzi:
Natl Hosp, Internal Med Res Inst, N-0027 Oslo, Norway Natl Hosp Oslo Norway N-0027 Internal Med Res Inst, N-0027 Oslo, Norway Univ Oslo, Natl Hosp, MSD Cardiovasc Res Ctr, Oslo, Norway Univ Oslo Oslo Norway , Natl Hosp, MSD Cardiovasc Res Ctr, Oslo, Norway Univ Oslo, Natl Hosp, Inst Surg Res, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Inst Surg Res, Oslo, Norway Univ Oslo, Natl Hosp, Dept Cardiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Dept Cardiol, Oslo, Norway Univ Oslo, Natl Hosp, Dept Med, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Oslo Oslo Norway Med, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Oslo, Natl Hosp, Dept Cardiothorac Surg, Oslo, Norway Univ Oslo Oslo Norway , Natl Hosp, Dept Cardiothorac Surg, Oslo, Norway Univ Oslo, Ulleval Hosp, Expt Med Res Inst, Oslo, Norway Univ Oslo Oslo Norway lo, Ulleval Hosp, Expt Med Res Inst, Oslo, Norway
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 5, volume: 31, anno: 2001,
pagine: 389 - 397
SICI:
0014-2972(200105)31:5<389:MGEOLI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE SIGNAL-TRANSDUCTION; TUMOR-NECROSIS-FACTOR; CARDIAC MYOCYTES; CIRCULATING LEVELS; GP130; ACTIVATION; RECEPTOR; CARDIOMYOPATHY; HYPERTROPHY; INFARCTION;
Keywords:
cytokines; gene expression; heart failure; immunology; myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Eiken, HG Natl Hosp, Internal Med Res Inst, N-0027 Oslo, Norway Natl HospOslo Norway N-0027 Med Res Inst, N-0027 Oslo, Norway
Citazione:
H.G. Eiken et al., "Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure", EUR J CL IN, 31(5), 2001, pp. 389-397

Abstract

Background Studies in different animal models and plasma analyses in humans suggest that members of the interleukin-6 (IL-6) cytokine family may be involved in the pathogenesis of congestive heart failure (CHF). Accordingly,we have examined IL-6-related cytokines in chronic CHF in humans by analysing gene and protein expression in myocardium derived from patients with end-stage heart failure and donor hearts. Methods Gene expression of cytokines/receptors of the IL-6 family was documented in myocardial samples using cDNA array hybridization and RNase protection assays. Immunohistochemistry was used to detect leukaemia inhibitory factor (LIF), IL-6 and glycoprotein 130 (gp130) in myocardial tissues. Results Myocardial gene activity was documented for the majority of IL-6 family cytokines and their receptors. Immunohistochemical analysis localizedIL-6, LIF and their common receptor subunit gp 130 to myocytes and vascular smooth muscle cells. LIF mRNA levels were enhanced in the left ventriclesof CHF patients relative to the left ventricles of donor hearts (patients 4.6 +/- 4.7 vs. donors 0.3 +/- 0.3, P < 0.005). Myocardial IL-6 and gp 130 mRNA levels were not statistically different between patients and donors, but in contrast to LIF mRNA expression in heart explants, gp130 mRNA levels were significantly higher in left atrium compared with left ventricle in both patients and donors. Conclusions Both mRNA and proteins of gp130 and its ligands IL-6 and LIF are expressed in both nonfailing and failing human myocardium. The elevated LIF mRNA levels in left ventricles from patients with end-stage heart failure suggest a role for LIF in the pathogenesis of CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:40:46