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Titolo:
Vascular inflammation and activation: new targets for lipid lowering
Autore:
Aikawa, M; Libby, P;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc,Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ardiovasc,Dept Med, Boston, MA 02115 USA
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: B, volume: 3, anno: 2001,
pagine: B3 - B11
SICI:
1520-765X(200105)3:B<B3:VIAANT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; LOW-DENSITY-LIPOPROTEIN; HMG-COA REDUCTASE; ACUTE CORONARY SYNDROMES; HUMAN ATHEROSCLEROTIC PLAQUES; ACUTE MYOCARDIAL-INFARCTION; AVERAGE CHOLESTEROL LEVELS; COLLAGEN GENE-EXPRESSION; TISSUE FACTOR EXPRESSION; HEAVY-CHAIN ISOFORMS;
Keywords:
lipid lowering; atheroma; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Aikawa, M Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc,Dept Med, 221Longwood Ave,LMRC309, Boston, MA 02115 USA Harvard Univ 221 Longwood Ave,LMRC309 Boston MA USA 02115 15 USA
Citazione:
M. Aikawa e P. Libby, "Vascular inflammation and activation: new targets for lipid lowering", EUR H J SUP, 3(B), 2001, pp. B3-B11

Abstract

Inflammatory cells, including macrophages, in atheroma overexpress matrix metalloproteinases (MMPs) and tissue factor which contribute to plaque rupture and thrombosis. Activated smooth muscle cells (SMCs) in the plaque's fibrous cap also express MMPs and tissue factor. Lipid lowering appears to reduce the incidence of acute coronary events in patients by stabilizing atherosclerotic plaques. To improve mechanistic understanding, we tested the hypothesis that experimental manipulation of cholesterol level improves features of atheroma related to their propensity to provoke acute thrombotic complications. In rabbits with established atheroma, dietary lipid lowering reduced accumulation of macrophages expressing MMPs and increased collagen, akey determinant of plaque stability. Lipid lowering also decreased expression of tissue factor and its inducer, CD40 ligand. SMCs in the fibrous cap of rabbit atheroma expressed less MMP and tissue factor after lipid lowering. We have recently found that treatment with an HMG-CoA reductase inhibitor, cerivastatin, retards macrophage accumulation in atheroma of Watanabe heritable hyperlipidaemic (WHHL) rabbits, probably in part by suppressing proliferation. Macrophage expression of MMPs and tissue factor also decreased with cerivastatin treatment in vivo and in vitro. These results support theview that lipid lowering reduces acute thrombotic complications of atherosclerosis in patients by attenuating vascular inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:17:53