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Titolo:
Different immune patterns in melancholic and non-melancholic major depression
Autore:
Rothermundt, M; Arolt, V; Fenker, J; Gutbrodt, H; Peters, M; Kirchner, H;
Indirizzi:
Univ Munster, Dept Psychiat, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Psychiat, D-48129 Munster, Germany Univ Lubeck, Sch Med, Inst Immunol & Transfus Med, Lubeck, Germany Univ Lubeck Lubeck Germany Inst Immunol & Transfus Med, Lubeck, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 2, volume: 251, anno: 2001,
pagine: 90 - 97
SICI:
0940-1334(200104)251:2<90:DIPIMA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; HYPOTHALAMIC-PITUITARY AXIS; CIRCULATING NATURAL-KILLER; RHEUMATOID-ARTHRITIS; LYMPHOCYTE FUNCTION; CYTOKINE PRODUCTION; ATYPICAL FEATURES; IN-VITRO; DISORDERS; SEVERITY;
Keywords:
major depression; melancholia; cytokines; immunology; immunocompetent cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Rothermundt, M Univ Munster, Dept Psychiat, Albert Schweitzer Str 11, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 11 Munster GermanyD-48129
Citazione:
M. Rothermundt et al., "Different immune patterns in melancholic and non-melancholic major depression", EUR ARCH PS, 251(2), 2001, pp. 90-97

Abstract

The search for immune patterns in major depression has thus far resulted in ambiguous findings, probably because patient samples are psychiatrically heterogeneous. We therefore focused on a detailed classification of subtypes of major depression, comparing patients with melancholic and non-melancholic major depression. Inpatients suffering from acute major depression were diagnosed and subclassified according to DSM IV criteria. Cell counts were determined by FAGS analysis and morphology. Cytokine production (IL-2, IFN-gamma, IL-10) upon mitogen stimulation was measured by ELISA in a whole blood assay. Non-melancholic patients showed increased counts of leukocytes, lymphocytes and NK-cells in the acute stage of disease and after two and four weeks of treatment. Their lymphokine production was unchanged compared to that of healthy controls. Melancholic patients on the other hand demonstrated normal cell counts but a decreased production of IL-2, IFN-gamma and IL-10 during the acute stage of disease followed by a normalization with clinical improvement. Melancholic and non-melancholic patients showed different immune patterns. Classifying melancholic and non-melancholic patients is helpful towards the identification of immune characteristics typical for these diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:39:39