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Titolo:
Effectiveness of targeted intervention and maintenance pharmacotherapy in conjunction with family intervention in schizophrenia
Autore:
Wiedemann, G; Hahlweg, K; Muller, U; Feinstein, E; Hank, G; Dose, M;
Indirizzi:
Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 herapy, D-72076 Tubingen, Germany Tech Univ Braunschweig, Inst Psychol, Braunschweig, Germany Tech Univ Braunschweig Braunschweig Germany chol, Braunschweig, Germany Max Planck Inst Psychiat, Inst Clin, Dept Psychiat, D-8000 Munich, GermanyMax Planck Inst Psychiat Munich Germany D-8000 t, D-8000 Munich, Germany Dist Hosp Taufkirchen Vils, Taufkirchen Vils, Germany Dist Hosp Taufkirchen Vils Taufkirchen Vils Germany rchen Vils, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 2, volume: 251, anno: 2001,
pagine: 72 - 84
SICI:
0940-1334(200104)251:2<72:EOTIAM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSED EMOTION; BEHAVIORAL INTERVENTION; NEUROLEPTIC WITHDRAWAL; FLUPHENAZINE DECANOATE; PREMORBID ADJUSTMENT; COMMUNITY MANAGEMENT; DEPOT NEUROLEPTICS; GERMAN MULTICENTER; CONTROLLED TRIAL; DOSE REDUCTION;
Keywords:
schizophrenia; relapse prevention; targeted intervention; intermittent medication; psychoeducational family therapy; behavioural family management;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Wiedemann, G Univ Tubingen, Dept Psychiat & Psychotherapy, Osianderstr 24,D-72076 Tubingen, Germany Univ Tubingen Osianderstr 24 Tubingen Germany D-72076 ermany
Citazione:
G. Wiedemann et al., "Effectiveness of targeted intervention and maintenance pharmacotherapy in conjunction with family intervention in schizophrenia", EUR ARCH PS, 251(2), 2001, pp. 72-84

Abstract

A sample of 85 patients with schizophrenia, of whom 34 later dropped out, received randomised treatment. There were no significant differences between treatment-takers and drop-outs in the variables assessed, patients received either standard-dose maintenance neuroleptic treatment or targeted maintenance pharmacotherapy and all patients received behavioural family therapy. Measures of psychopathology, social adjustment, side-effects, family burden, and expressed emotion were assessed at baseline and then periodically over an 18-month period. The study was designed to compare the two alternative pharmacological maintenance approaches, each of them supported by psychosocial intervention. Any evaluation of the impact of behavioural family treatment on relapse rates and other outcome criteria is exclusively descriptive. A significantly higher rate of relapse was observed at 18 months in patients randomised to targeted treatment compared to those randomised to standard-dose treatment (35 % vs 4 %). Although patients assigned to the targeted maintenance group received significantly lower mean doses of neuroleptics, there were no significant differences between the two groups with regardto side-effects, global measures of social function, and overall psychopathology. Family burden was higher in the targeted-treatment group at six months, but did not differ at the one-year and eighteen-month time points. However, both groups improved significantly from baseline to 12 or 18 months in almost all variables assessed. Thus, the behavioural family approach did not compensate for the problems associated with the targeted medication strategy.

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Documento generato il 26/01/20 alle ore 09:49:57