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Titolo:
Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test - a fMRI study
Autore:
Riehemann, S; Volz, HP; Stutzer, P; Smesny, S; Gaser, C; Sauer, H;
Indirizzi:
Fraunhofer Inst Appl Opt & Precis Engn, D-07745 Jena, Germany Fraunhofer Inst Appl Opt & Precis Engn Jena Germany D-07745 ena, Germany Univ Jena, Dept Psychiat, D-07743 Jena, Germany Univ Jena Jena Germany D-07743 ena, Dept Psychiat, D-07743 Jena, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 2, volume: 251, anno: 2001,
pagine: 66 - 71
SICI:
0940-1334(200104)251:2<66:HINSPD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; NEWLY-DIAGNOSED SCHIZOPHRENIA; EMISSION COMPUTED-TOMOGRAPHY; COGNITIVE STIMULATION; ACTIVATION; SPECT; DYSFUNCTION; DISORDER; ABNORMALITIES; DISEASE;
Keywords:
schizophrenia; neuroleptic-naive; functional neuroimaging; hypofrontality; WCST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Riehemann, S Fraunhofer Inst Appl Opt & Precis Engn, Schillerstr 1, D-07745 Jena, Germany Fraunhofer Inst Appl Opt & Precis Engn Schillerstr 1 Jena Germany D-07745
Citazione:
S. Riehemann et al., "Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test - a fMRI study", EUR ARCH PS, 251(2), 2001, pp. 66-71

Abstract

Functional neuroimaging findings "hypofrontality" in schizophrenic patients - as tested with the Wisconsin Card Sorting Test (WCST) - are still controversial, mainly due to methodological aspects and the heterogeneity of thepatient samples. To measure WCST specific and reproducible reduced cerebral activations in schizophrenic patients, we revised the study design and patient recruitment, respectively. For this purpose, we used an adequate active control task instead of an undefined rest condition to determine exclusively WCST specific cerebral activations. In addition, we focused on the investigation of modified activations between a selected group of neuroleptic-naive schizophrenic patients and carefully matched healthy controls by means of functional magnetic resonance imaging. The results indicate that neuroleptic-naive schizophrenic patients show reduced activations in the right frontal and left temporal lobe, as well as in the left cerebellum. By utilizing an active control task all unwanted activations are suppressed. Furthermore the influence of different task performances is reduced. The findings are in line with previous PET and SPECT studies and confirm the "hypofrontality" hypothesis. The findings suggest that"hypofrontality" is not caused by neuroleptic medication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 16:59:45