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Titolo:
The metaplastic effects of estrogen on mouse prostate epithelium: Proliferation of cells with basal cell phenotype
Autore:
Risbridger, GP; Wang, H; Frydenberg, M; Cunha, G;
Indirizzi:
Monash Med Ctr, Inst Reprod & Dev, Ctr Urol Res, Melbourne, Vic 3168, Australia Monash Med Ctr Melbourne Vic Australia 3168 elbourne, Vic 3168, Australia Monash Univ, Monash Med Ctr, Dept Urol, Melbourne, Vic 3168, Australia Monash Univ Melbourne Vic Australia 3168 , Melbourne, Vic 3168, Australia Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 6, volume: 142, anno: 2001,
pagine: 2443 - 2450
SICI:
0013-7227(200106)142:6<2443:TMEOEO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PROSTATE; RECEPTOR EXPRESSION; REPRODUCTIVE-ORGANS; ANDROGEN; GROWTH; PROGESTERONE; DISRUPTION; ESTRADIOL; EXPOSURE; LOBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Risbridger, GP Monash Med Ctr, Inst Reprod & Dev, Ctr Urol Res, 246 Clayton Rd, Melbourne, Vic 3168, Australia Monash Med Ctr 246 Clayton Rd Melbourne Vic Australia 3168
Citazione:
G.P. Risbridger et al., "The metaplastic effects of estrogen on mouse prostate epithelium: Proliferation of cells with basal cell phenotype", ENDOCRINOL, 142(6), 2001, pp. 2443-2450

Abstract

The exogenous administration of estrogens to male mice alters the hypothalamic-pituitary-gonadal axis and reduces androgen levels, leading to a regression of the prostatic epithelium. As well, a specific direct response to estrogens is the induction of epithelial squamous metaplasia. The aims of this study were to identify the process by which the prostatic epithelium is transformed in intact adult male mice using the synthetic estrogen, diethylstilbestrol. A comparison of the effects of diethylstilbestrol in the threelobes revealed a hierarchy of response, with the anterior lobe being the most responsive, the dorsolateral lobe less responsive, and the ventral lobethe least responsive. The effect of castration was used to distinguish between the epithelial responses to estrogen administration and androgen deprivation. The results demonstrate that transformation of the epithelium involved proliferation of cells with a basal cell phenotype, the onset of cytokeratin 10 expression, up-regulation of progesterone receptor expression, andloss of the cell cycle inhibitor, p27(Kip1) expression; none of these changes was observed after castration. Mice lacking functional estrogen receptor a failed to respond, demonstrating a requirement for estrogen receptor a in the epithelium and/or stroma to mediate the proliferative response to estrogen in the prostate gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:42:59