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Titolo:
Cloning and characterization of a novel gene that is regulated by estrogenand is associated with mammary gland carcinogenesis
Autore:
Marcantonio, D; Chalifour, LE; Alaoui-Jamali, MA; Alpert, L; Huynh, HT;
Indirizzi:
McGill Univ, Lady Davis Inst Med Res, Sir Mortimer B Davis Jewish Gen Hosp, Dept Med, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 Med, Montreal, PQ H3T 1E2, Canada McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 peut, Montreal, PQ H3T 1E2, Canada McGill Univ, Dept Pathol & Oncol, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 ncol, Montreal, PQ H3T 1E2, Canada
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 6, volume: 142, anno: 2001,
pagine: 2409 - 2418
SICI:
0013-7227(200106)142:6<2409:CACOAN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; GROWTH-FACTOR; CELL-PROLIFERATION; MESSENGER-RNA; EXPRESSION; RECEPTOR; TUMORS; ESTRADIOL; TAMOXIFEN; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chalifour, LE McGill Univ, Lady Davis Inst Med Res, Sir Mortimer B Davis Jewish Gen Hosp, Dept Med, 3755 Chemin Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada McGill Univ 3755 Chemin Cote Ste Catherine Montreal PQ Canada H3T 1E2
Citazione:
D. Marcantonio et al., "Cloning and characterization of a novel gene that is regulated by estrogenand is associated with mammary gland carcinogenesis", ENDOCRINOL, 142(6), 2001, pp. 2409-2418

Abstract

Estrogens play a role in mammary gland function and are implicated in mammary carcinogenesis. We report the cloning of a novel gene [steroid-sensitive gene 1 (SSG1)] that is regulated by E, in the rat uterus and mammary gland. The full-length SSG1 complementary DNA has an open reading frame of 1158nucleotides encoding a putative protein of 385 amino acids. A SSG1-specific antibody recognizes a 40-kDa protein localized to myoepithelial cells of normal mammary tissue and to endothelial cells of 7,12-dimethylbenz(a)antracene-induced mammary tumors. Treatment of rats with E-2 at 1.2 or 2.4 mug/kg.day for 21 days increases SSG1 protein levels in mammary tissue by 16-fold compared with controls. Removal of E-2 after a 14-day treatment decreasesSSG1 protein levels 6-fold and 3-fold at 120 and 144 h, respectively. Treatment of rats with the estrogen antagonists tamoxifen or ICI 182,780 did not affect SSG1 protein levels compared with controls. SSG1 protein levels in7,12-dimethylbenz(a)antracene-induced rat mammary tumors were 23-fold greater than SSG1 levels in resting mammary tissue, and 8-fold higher than protein levels expressed in lactating mammary glands. We propose that SSG1 plays a role in estrogen functions, and its overexpression is correlated with mammary carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:12:46