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Titolo:
Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat
Autore:
Zhao, SP; Fields, PA; Sherwood, OD;
Indirizzi:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Coll Med, Urbana, IL 61801 USA Univ Illinois Urbana IL USA61801 llinois, Coll Med, Urbana, IL 61801 USA Univ S Alabama, Coll Med, Dept Cellular Struct Biol, Mobile, AL 36688 USA Univ S Alabama Mobile AL USA 36688 ular Struct Biol, Mobile, AL 36688 USA
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 6, volume: 142, anno: 2001,
pagine: 2221 - 2229
SICI:
0013-7227(200106)142:6<2221:ETRIAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; GROWTH-FACTOR-I; MONOCLONAL-ANTIBODIES; PASSIVE-IMMUNIZATION; INTACT RATS; 2ND HALF; PROMOTES GROWTH; DISRUPTS BIRTH; ESTROUS-CYCLE; 2ND-HALF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sherwood, OD Univ Illinois, Dept Mol & Integrat Physiol, 524 Burrill Hall,407 S GoodwinAve, Urbana, IL 61801 USA Univ Illinois 524 Burrill Hall,407 SGoodwin Ave Urbana IL USA 61801
Citazione:
S.P. Zhao et al., "Evidence that relaxin inhibits apoptosis in the cervix and the vagina during the second half of pregnancy in the rat", ENDOCRINOL, 142(6), 2001, pp. 2221-2229

Abstract

The growth of the cervix and vagina that occurs during the second half of rat pregnancy is accompanied by an increase in both epithelial and stromal cells. Neither the mechanism(s) that regulates this accumulation of cells nor its hormonal control is known. To test the hypothesis that the rate of apoptosis declines during the second half of pregnancy, cervices and vaginaswere collected on days 5, 10, 15, 18, and 21 of pregnancy. Terminal deoxynucleotidyl transferase-mediated deoxyuridine 5'-triphosphate nick end-labeling was used to detect apoptotic cells. The rate of apoptosis declined (P <0.05) in epithelial and stromal cells in both the cervix and vagina duringthe second half of pregnancy, when blood levels of relaxin are increasing. To test the hypothesis that relaxin inhibits apoptosis, cervices and vaginas were collected 6, 12, 24, 48, and 72 h after the neutralization of endogenous relaxin, on days 19-21 of pregnancy, with a monoclonal antibody for rat relaxin. Both the terminal deoxynucleotidyl transferase-mediated deoxyuridine 5'-triphosphate nick end-labeling method and electron microscopy wereused to detect apoptotic cells. Withdrawal of relaxin caused an increase in the rate of apoptosis in both the cervix and the vagina (P < 0.05). It isconcluded that the rate of apoptosis declines in the cervix and the vaginaduring the second half of rat pregnancy, and that relaxin likely contributes to this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:59:18