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Titolo:
Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function
Autore:
Jones, N; Voskas, D; Master, Z; Sarao, R; Jones, J; Dumont, DJ;
Indirizzi:
Sunnybrook & Womens Coll, Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll Toronto ON Canada M4N 3M5 to, ON M4N 3M5, Canada Univ Toronto, Dept Med Biophys, Toronto, ON, Canada Univ Toronto Toronto ON Canada to, Dept Med Biophys, Toronto, ON, Canada Toronto Sunnybrook Reg Canc Ctr, Toronto, ON, Canada Toronto Sunnybrook Reg Canc Ctr Toronto ON Canada r, Toronto, ON, Canada Amgen Inst, Toronto, ON M5G 2C1, Canada Amgen Inst Toronto ON Canada M5G 2C1 en Inst, Toronto, ON M5G 2C1, Canada
Titolo Testata:
EMBO REPORTS
fascicolo: 5, volume: 2, anno: 2001,
pagine: 438 - 445
SICI:
1469-221X(200105)2:5<438:ROTEVD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; SIGNAL-TRANSDUCTION PATHWAY; ENDOTHELIAL-CELL SURVIVAL; BLOOD-VESSEL FORMATION; TIE2 RECEPTOR; EMBRYONIC ANGIOGENESIS; GENE-EXPRESSION; TRANSGENIC MICE; TEK; ANGIOPOIETIN-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dumont, DJ Sunnybrook & Womens Coll, Hlth Sci Ctr, 2075 Bayview Ave,Res Bldg S-227, Toronto, ON M4N 3M5, Canada Sunnybrook & Womens Coll 2075 BayviewAve,Res Bldg S-227 Toronto ON Canada M4N 3M5
Citazione:
N. Jones et al., "Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function", EMBO REP, 2(5), 2001, pp. 438-445

Abstract

Disruption of the signaling pathways mediated by the receptor tyrosine kinase Tek/Tie2 has shown that this receptor plays a pivotal role in vascularization of the developing embryo. In this report, we have utilized the tetracycline-responsive binary transgenic system to overcome the early lethal cardiovascular defects associated with the tek(Delta sP) null allele in orderto investigate the role of Tek in later stages of vessel growth. We show for the first time in vivo that synchronized loss of tek expression correlates with rapid endothelial cell apoptosis in hemorrhagic regions of the embryo, demonstrating an ongoing requirement for Tek-mediated signal transduction in vascular maintenance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:14:50