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Titolo:
Ecological fitness, genomic islands and bacterial pathogenicity - A Darwinian view of the evolution of microbes
Autore:
Hacker, J; Carniel, E;
Indirizzi:
Univ Wurzburg, Inst Mol Infelt Biol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 t Biol, D-97070 Wurzburg, Germany Inst Pasteur, Unite Bacteriol Mol & Med, Yersinia Lab, F-75724 Paris 15, France Inst Pasteur Paris France 15 Med, Yersinia Lab, F-75724 Paris 15, France
Titolo Testata:
EMBO REPORTS
fascicolo: 5, volume: 2, anno: 2001,
pagine: 376 - 381
SICI:
1469-221X(200105)2:5<376:EFGIAB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORIZONTAL GENE-TRANSFER; ESCHERICHIA-COLI; YERSINIA-PSEUDOTUBERCULOSIS; MOLECULAR MECHANISMS; PATHOGENESIS; SYMBIOSIS; IMPACT; DNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hacker, J Univ Wurzburg, Inst Mol Infelt Biol, Rontgenring 11, D-97070 Wurzburg, Germany Univ Wurzburg Rontgenring 11 Wurzburg Germany D-97070 , Germany
Citazione:
J. Hacker e E. Carniel, "Ecological fitness, genomic islands and bacterial pathogenicity - A Darwinian view of the evolution of microbes", EMBO REP, 2(5), 2001, pp. 376-381

Abstract

The compositions of bacterial genomes can be changed rapidly and dramatically through a variety of processes including horizontal gene transfer. Thisform of change is key to bacterial evolution, as it leads to 'evolution inquantum leaps'. Horizontal gene transfer entails the incorporation of genetic elements transferred from another organism-perhaps in an earlier generation - directly into the genome, where they form 'genomic islands', i.e. blocks of DNA with signatures of mobile genetic elements. Genomic islands whose functions increase bacterial fitness, either directly or indirectly, have most likely been positively selected and can be termed 'fitness islands'. Fitness islands can be divided into several subtypes: 'ecological islands'in environmental bacteria and 'saprophytic islands', 'symbiosis islands' or 'pathogenicity islands' (PAIs) in microorganisms that interact with living hosts. Here we discuss ways in which PAIs contribute to the pathogenic potency of bacteria, and the idea that genetic entities similar to genomic islands may also be present in the genomes of eukaryotes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:18:39