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Titolo:
Interferon-related thyroid autoimmunity and long-term clinical outcome of chronic hepatitis C
Autore:
Morisco, F; Mazziotti, G; Rotondi, M; Tuccillo, C; Iasevoli, P; Del Buono, A; Sorvillo, F; Amato, G; Marmo, R; Caporaso, N; Carella, C;
Indirizzi:
Univ Naples Federico II, Dept Food Sci, Portici, NA, Italy Univ Naples Federico II Portici NA Italy pt Food Sci, Portici, NA, Italy Univ Naples 2, Inst Endocrinol, Naples, Italy Univ Naples 2 Naples Italy niv Naples 2, Inst Endocrinol, Naples, Italy Univ Naples 2, Dept Internal Med F Magrassi, Naples, Italy Univ Naples 2 Naples Italy Dept Internal Med F Magrassi, Naples, Italy Polla Hosp, Gastroenterol Unit, Polla, SA, Italy Polla Hosp Polla SA Italy lla Hosp, Gastroenterol Unit, Polla, SA, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 3, volume: 33, anno: 2001,
pagine: 247 - 253
SICI:
1590-8658(200104)33:3<247:ITAALC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC VIRAL-HEPATITIS; ALPHA-INTERFERON; MULTIPLE-SCLEROSIS; BETA THERAPY; HCV; DYSFUNCTION; INFECTION; DISEASE; VIRUS; HYPOTHYROIDISM;
Keywords:
autoimmune thyroiditis; hepatitis C virus infection; interferon therapy; liver disease progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Caporaso, N Via Caravaglios 36, I-80125 Naples, Italy Via Caravaglios 36 Naples Italy I-80125 -80125 Naples, Italy
Citazione:
F. Morisco et al., "Interferon-related thyroid autoimmunity and long-term clinical outcome of chronic hepatitis C", DIG LIVER D, 33(3), 2001, pp. 247-253

Abstract

Background. A high incidence of thyroid autoantibodies and/or disorders was observed in subjects with hepatitis C virus-related chronic hepatitis during interferon-alpha therapy. Aim. To evaluate whether thyroid autoimmunity and dysfunction, induced by interferon-alpha therapy, could be viewed as predictors for treatment response and as valid prognostic markers of liver disease progression. Patients. A total of 136 subjects (96 males/40 females; median age 48 years; range 23-64) affected by biopsy-proven chronic hepatitis C (33.1% with compensated liver cirrhosis). Methods. All subjects were treated with interferon-alpha therapy at 6 MU 3times weekly for 12 months and then followed up for an average period of 60 months (range 12-108). Routine laboratory tests, virological assessment, liver ultrasound, thyroid function tests (serum free-triiodothyronine, free-thyroxine, serum thyrotropin), and autoimmunity were performed for all subjects. Results. Percentage of thyroid autoimmunity and thyroid dysfunction in long-term responders was not significantly different compared to that in non-responders (47.0% and 11.8% vs 35.3% and 5.9%, respectively; non significant). The multivariate model demonstrated that the absence of cirrhosis was the only factor significantly related to successful response to therapy (oddsratio: 14.9; 95% confidence interval: 1.9-115.0 for chronic hepatitis C vspresence of cirrhosis). Moreover: the occurrence of thyroid autoimmunity during interferon therapy was similar both in patients with or without worsening of liver disease (33.3% and 39.8%, respectively; p = not significant). No subject with on-going liver disease developed thyroid dysfunction during treatment, as opposed to the 10/118 (8.4%) with a better course of liver disease; however: this difference was not statistically significant. The multivariate model showed that age was the only covariate significantly associated with unfavourable outcome of liver disease (odds ratio: 18.6; 95% confidence interval: 2.3-151.9, for those over 48 years vs younger patients). Conclusions. There is no evidence that the immune mechanism involved in the pathogenesis of thyroid autoimmune phenomena is the same as that regulating the therapeutic clearance of HCV or modulating the unfavourable course of HCV-related chronic hepatitis. However: our study confirmed that liver disease seems to progress more slowly in younger subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:28:32