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Titolo:
Interactions between metabolic disorders [diabetes, gallstones, and dyslipidaemia] and the progression of chronic hepatitis C virus infection to cirrhosis and hepatocellular carcinoma. A cross-sectional multicentre survey
Autore:
Cimino, L; Oriani, G; DArienzo, A; Manguso, F; Loguercio, C; Ascione, A; Caporaso, N; Blanco, CD; Budillon, G;
Indirizzi:
Univ Naples Federico II, Fac Med & Chirurg, Cattedra Gastroentrol, I-80131Naples, Italy Univ Naples Federico II Naples Italy I-80131 ntrol, I-80131Naples, Italy Univ Naples Federico II, Dept Clin & Expt Med, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 Med, I-80131 Naples, Italy Univ Molise, Dept SAVA, Campobasso, Italy Univ Molise Campobasso ItalyUniv Molise, Dept SAVA, Campobasso, Italy Osped Antonio Cardarelli, Operat Unit Liver Physiopathol, Naples, Italy Osped Antonio Cardarelli Naples Italy Liver Physiopathol, Naples, Italy Univ Naples Federico II, Dept Alimentary Sci, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 Sci, I-80131 Naples, Italy Univ Naples 2, Dept Internal Med F Magrassi, Naples, Italy Univ Naples 2 Naples Italy Dept Internal Med F Magrassi, Naples, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 3, volume: 33, anno: 2001,
pagine: 240 - 246
SICI:
1590-8658(200104)33:3<240:IBMD[G>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; THERAPEUTIC APPLICATIONS; LIPOPROTEIN ALTERATIONS; URSODEOXYCHOLIC ACID; RISK-FACTORS; MELLITUS; MECHANISMS; CHOLELITHIASIS; EPIDEMIOLOGY;
Keywords:
cholestasis; diabetes; hepatitis C virus; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Cimino, L Univ Naples Federico II, Fac Med & Chirurg, Cattedra Gastroentrol, Via S Pansini 5, I-80131 Naples, Italy Univ Naples Federico II Via S Pansini 5 Naples Italy I-80131 ly
Citazione:
L. Cimino et al., "Interactions between metabolic disorders [diabetes, gallstones, and dyslipidaemia] and the progression of chronic hepatitis C virus infection to cirrhosis and hepatocellular carcinoma. A cross-sectional multicentre survey", DIG LIVER D, 33(3), 2001, pp. 240-246

Abstract

Background. Diabetes, gallstones and dyslipidaemia are widespread, metabolically related, disorders that can affect the liver: often in a clinically silent fashion. Aim. To investigate whether the presence of these disorders may worsen chronic viral disease by inducing additional liver damage, revealed by variations in serum increases of aminotransferase, alkaline phosphatase and gamma-glutamyl-transpeptidase activities. Patients and methods. This retrospective, cross-sectional study involved 1195 patients with chronic hepatitis C virus infection: 47.2% chronic hepatitis, 45.2% cirrhosis, and 7.6% hepatocellular carcinoma. 14.9% of patients had enzymatic cholestasis, defined as combined increase of alkaline phosphatase and gamma-glutamyl-transpeptidase. A Log-linear statistical model was applied to the following variables: stages of liver disease, diabetes, cholelithiasis, hypertriglyceridaemia, hypercholesterolaemia, and enzymatic cholestasis. Results. Log-linear analysis, applied to categorical variables, revealed, for the first time, a three-way interaction between the stages of chronic liver disease, diabetes, and enzymatic cholestasis. Two-way interactions demonstrated that liver disease stages correlated directly to the prevalence of cholelithiasis and inversely to hypercholesterolaemia. Irrespective of the liver disease stage, hypertriglyceridaemia correlated to hypercholesterolaemia. Conclusions. This study discloses a synergistic liver damaging effect of diabetes and hepatitis C virus. The three-way interaction obtained by our analysis suggests that diabetes is a risk factor for the progression of viralliver disease and that it contributes to disease evolution, at least in part, by induction of cholestasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:40:44