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Titolo:
Prevalence of Helicobacter pylori infection in coronary artery disease andeffect of its eradication on coronary lumen reduction after percutaneous coronary angioplasty
Autore:
Kowalski, M; Konturek, PC; Pieniazek, P; Karczewska, E; Kluczka, A; Grove, R; Kranig, W; Nasseri, R; Thale, J; Hahn, EG; Konturek, SJ;
Indirizzi:
Jagiellonian Univ, Coll Med, Dept Physiol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 hysiol, PL-31531 Krakow, Poland Hertzctr Osnabruck Bad Rothenfelde, Osnabruck, Germany Hertzctr Osnabruck Bad Rothenfelde Osnabruck Germany Osnabruck, Germany Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany rg, Dept Med, Erlangen, Germany
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 3, volume: 33, anno: 2001,
pagine: 222 - 229
SICI:
1590-8658(200104)33:3<222:POHPII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; GASTRIC EPITHELIAL-CELLS; C-REACTIVE PROTEIN; CHLAMYDIA-PNEUMONIAE; CAGA PROTEIN; ASSOCIATION; ATHEROSCLEROSIS; TRANSLOCATION; POPULATION;
Keywords:
CagA; Chlamydia pneumoniae; coronary artery disease; Helicobacter pylori; IgG; immune response; inflammation; interleukins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Konturek, SJ Jagiellonian Univ, Coll Med, Dept Physiol, Grzegorzecka 16, PL-31531 Krakow, Poland Jagiellonian Univ Grzegorzecka 16 Krakow Poland PL-31531 and
Citazione:
M. Kowalski et al., "Prevalence of Helicobacter pylori infection in coronary artery disease andeffect of its eradication on coronary lumen reduction after percutaneous coronary angioplasty", DIG LIVER D, 33(3), 2001, pp. 222-229

Abstract

Background. Gastric infection caused by Helicobacter pylori has recently been associated with increased risk of coronary artery disease. Aim. To: 1) determine seroprevalence of Helicobacter pylori and its cytotoxin associated gene A in patients with/without coronary artery disease (group A), 2) assess influence of Helicobacter pylori eradication on coronary artery lumen reduction after percutaneous coronary angioplasty (group B) and3) determine influence of Helicobacter pylori eradication on plasma cytokines, lipids and coagulation factors in patients subjected to percutaneous coronary angioplasty (group B). Patients and methods. Group A included 100 patients with coronary artery disease (subgroup I) and 100 patients without (subgroup II). For Helicobacter pylori seroprevalence, plasma anti-Helicobacter pylori and anti-cytotoxinassociated gene A IgG were examined. Group B included 40 patients with significant single-vessel coronary arterial disease and Helicobacter pylori infection confirmed by C-13-urea breath test and serologically using anti-Helicobacter pylori and anti-cytotoxin associated gene A IgG. Six months afterpercutaneous coronary angioplasty and triple anti-Helicobacter pylori therapy, the Helicobacter pylori status reassessed by urea breath test was negative in all but two patients of subgroup I subjected to Helicobacter pyloritherapy. Coronary angiography and laboratory tests were repeated in both subgroups of group B included in the trial and reduction in coronary artery lumen in these subgroups was compared to baseline after percutaneous coronary angioplasty considered as 100%. Results. Helicobacter pylori seropositivity reached 81.5% of coronary artery disease (subgroup II and was significantly higher than that in controls without coronary artery disease (subgroup II) (51%), the adds ratio being 4.3 for Helicobacter pylori in coronary artery disease. Cytotoxin associatedgene A IgG detection was also significantly higher (47.3%) in coronary artery disease than in controls (28%) giving the odds ratio about 2. 3. Mean coronary artery lumen reduction in patients undergoing percutaneous coronaryangioplasty + Helicobacter pylori eradication therapy (subgroup I) was significantly (p <0.05) smaller compared to percutaneous coronary angioplasty placebo-treated subgroup II (22% vs 41%). Conclusions. 1) There is a significant link between coronary artery disease and infection with Helicobacter pylori, especially expressing CagA proteins, 2) Helicobacter pylori eradication significantly attenuates reduction in coronary artery lumen in coronary artery disease patients after percutaneous coronary angioplasty possibly by elimination of chronic inflammation and decline in proinflammatory cytokine release, and 3) Infection of Chlamydia pneumoniae in these percutaneous coronary angioplasty patients is not affected by eradication therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 10:24:23