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Titolo:
Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease
Autore:
Kesavulu, MM; Rao, BK; Giri, R; Vijaya, J; Subramanyam, G; Apparao, C;
Indirizzi:
Sri Venkateswara Univ, Sch Biol & Earth Sci, Dept Biochem, Tirupati 517502, Andhra Pradesh, India Sri Venkateswara Univ Tirupati Andhra Pradesh India 517502 Pradesh, India SVRRGH & SV Med Coll, Dept Cardiol, Tirupati, Andhra Pradesh, India SVRRGH& SV Med Coll Tirupati Andhra Pradesh India Andhra Pradesh, India
Titolo Testata:
DIABETES RESEARCH AND CLINICAL PRACTICE
fascicolo: 1, volume: 53, anno: 2001,
pagine: 33 - 39
SICI:
0168-8227(200107)53:1<33:LPAAES>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; PLASMA-LIPIDS; MELLITUS; CHOLESTEROL; SERUM; COMPLICATIONS; ERYTHROCYTES; CATALASE;
Keywords:
(non-)insulin-dependent diabetes mellitus [(N)IDDM]; lipid peroxidation; thiobarbituric acid reactive substances (TBARS); antioxidant enzymes; coronary heart disease (CHD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Apparao, C Sri Venkateswara Univ, Sch Biol & Earth Sci, Dept Biochem, Tirupati 517502, Andhra Pradesh, India Sri Venkateswara Univ Tirupati Andhra Pradesh India 517502 dia
Citazione:
M.M. Kesavulu et al., "Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease", DIABET RE C, 53(1), 2001, pp. 33-39

Abstract

Lipid peroxides are thought to be formed by free radicals and may play an important role in the development of atheromatous vascular diseases. The relationship between serum lipids, lipoproteins, lipid peroxides [thiobarbituric acid reactive substances (TBARS)] and erythrocyte antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD)] was investigated in non-insulin-dependent diabetic patients with and without coronary heart disease (CHD), and a comparison was made for all the above parameters with non-diabetic patients with CHD. Lipid peroxide concentrations were significantly increased in both groups of diabetic patients and also in non-diabetic patients with CHD, compared to those in control subjects. Diabetic patients with CHD had higher levels of TEARS compared to thosediabetics without CHD. Hyperlipidaemia and abnormal lipoprotein levels were observed in all three groups of patients. Increased total cholesterol andLDL-cholesterol were observed in diabetics with CHD compared to those without CHD. Among the erythrocyte antioxidant enzymes, CAT activity was increased, GPx activity was decreased and no change was observed in SOD activity in both groups of diabetic patients and non-diabetic patients with CHD compared to those in controls. A clear correlation was observed between the CATactivity and lipid peroxide concentrations in all the diabetic patients. These observations suggest that there are similar abnormalities in lipid metabolism and erythrocyte antioxidant enzymes in diabetic patients and non-diabetic patients with CHD. (C) 2001 Elsevier Science Ireland Ltd. All rightsreserved.

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Documento generato il 05/12/20 alle ore 18:54:30