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Titolo:
Lipid and blood pressure treatment goals for type 1 diabetes - 10-year incidence data from the Pittsburgh Epidemiology of Diabetes Complications Study
Autore:
Orchard, TJ; Kuller, LH; Forrest, KYZ; Becker, DJ;
Indirizzi:
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 idemiol, Pittsburgh, PA 15213 USA Slippery Rock Univ, Dept Allied Hlth, Slippery Rock, PA USA Slippery Rock Univ Slippery Rock PA USA lied Hlth, Slippery Rock, PA USA Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pediat, Pittsburgh, PA 15261 USA
Titolo Testata:
DIABETES CARE
fascicolo: 6, volume: 24, anno: 2001,
pagine: 1053 - 1059
SICI:
0149-5992(200106)24:6<1053:LABPTG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR MORTALITY; RENAL-FUNCTION; RISK-FACTORS; MELLITUS; IDDM; RETINOPATHY; HYPERTENSION; NEPHROPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Orchard, TJ Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, DLR Bldg,3512 5th Ave, Pittsburgh, PA 15213 USA Univ Pittsburgh DLR Bldg,3512 5th Ave Pittsburgh PA USA 15213
Citazione:
T.J. Orchard et al., "Lipid and blood pressure treatment goals for type 1 diabetes - 10-year incidence data from the Pittsburgh Epidemiology of Diabetes Complications Study", DIABET CARE, 24(6), 2001, pp. 1053-1059

Abstract

OBJECTIVE - Subjects with type 1 diabetes are at high risk for many long-term complications, including early mortality and coronary artery disease (CAD). Few data are available on which to base goal levels for two major riskfactors, namely blood pressure and lipid/lipoproteins. The objective of this study was to determine at which levels of LDL and HDL cholesterol, triglycerides, and blood pressure the relative risks of type 1 diabetic complications increase significantly. RESEARCH DESIGN AND METHODS - Observational prospective study of 589 patients with childhood-onset type 1 diabetes (<17 years) aged <greater than or equal to>18 years at baseline; 10-year incidence of mortality, CAD, lower-extremity arterial disease, proliferative retinopathy, distal symmetric polyneuropathy, and overt nephropathy. Relative risks were determined using traditional groupings of blood pressure and lipid/lipoproteins, measured at baseline, using the lowest groupings (<100 mg/dl [2.5 mmol/l] LDL cholesterol, <45 mg/dl [1.1 mmol/l] HDL cholesterol, <100 mg/dl [1.1 mmol/l] triglycerides, <110 mmHg systolic blood pressure, and <80 mmHg diastolic blood pressure) as reference. Adjustments for age, sex, and glycemic control were examined. RESULTS - Driven mainly by strong relationships (RR range 1.8-12.1) with mortality, CAD, and overt nephropathy, suggested goal levels are as follows:LDL cholesterol <100 mg/dl (2.6 mmol/l), HDL cholesterol >45 mg/dl (1.1 mmol/l), triglycerides <150 mg/dl(1.7 mmol/l), systolic blood pressure <120 mmHg, and diastolic blood pressure <80 mmHg. Age, sex, and glycemic control had little influence on these goals. CONCLUSIONS - Although observational in nature, these data strongly support the case for vigorous control of lipid levels and blood pressure in patients with type 1 diabetes.

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Documento generato il 19/01/20 alle ore 20:25:02