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Titolo:
Towards a cellular and molecular understanding of neurulation
Autore:
Colas, JF; Schoenwolf, GC;
Indirizzi:
Univ Utah, Sch Med, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 Anat, Salt Lake City, UT 84132 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 2, volume: 221, anno: 2001,
pagine: 117 - 145
SICI:
1058-8388(200106)221:2<117:TACAMU>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE DEFECTS; DROSOPHILA GERMBAND EXTENSION; GENERIC PHYSICAL-MECHANISMS; ABNORMAL BRAIN-DEVELOPMENT; LOOP-HELIX FACTORS; APO-B GENE; MICE LACKING; MOUSE EMBRYOS; CHICK-EMBRYO; SECONDARY NEURULATION;
Keywords:
biophysical determinants of form; canalization of development; cell behaviors; central nervous system; chick embryo; folic acid; genes; heredity; mouse knockouts; morphogenesis; neural folds; neural groove; neural plate; neural tube defects (NTDs); neurulation defects;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
232
Recensione:
Indirizzi per estratti:
Indirizzo: Schoenwolf, GC Univ Utah, Sch Med, Dept Neurobiol & Anat, 50 N Med Dr, Salt Lake City, UT84132 USA Univ Utah 50 N Med Dr Salt Lake City UT USA 84132 84132 USA
Citazione:
J.F. Colas e G.C. Schoenwolf, "Towards a cellular and molecular understanding of neurulation", DEV DYNAM, 221(2), 2001, pp. 117-145

Abstract

Neurulation occurs during cause early embryogenesis of chordates, and it the early embryogenesis of chordates, and it results in the formation of theneural tube, a dorsal hollow nerve cord that constitutes the rudiment of the entire adult central nervous system. The goal of studies on neurulation is to understand its tissue, cellular and molecular basis, as well as how neurulation is perturbed during the formation of neural tube defects. The tissue basis of neurulation consists of a series of coordinated morphogeneticmovements within the primitive streak (e.g., regression of Hensen's node) and nascent primary germ layers formed during gastrulation. Signaling occurs between Hensen's node and the nascent ectoderm, initiating neurulation byinducing the neural plate (i.e., actually, by suppressing development of the epidermal ectoderm). Tissue movements subsequently result in shaping andbending of the neural plate and closure of the neural groove. The cellularbasis of the tissue movements of neurulation consists of changes in the behavior of the constituent cells; namely, changes in cell number, position, shape, size and adhesion. Neurulation, like any morphogenetic event, occurswithin the milieu of generic biophysical determinants of form present in all, living tissues. Such forces govern and to some degree control morphogenesis in a tissue-autonomous manner. The molecular basis of neurulation remains largely unknown, but we suggest that neurulation genes have evolved to work in concert with such determinants, so that appropriate changes occur in the behaviors of the correct populations of cells at the correct time, maximizing the efficiency of neurulation and leading to heritable species-andaxial-differences in this process. In this article, we review the tissue and cellular basis of neurulation and provide strategies to determine its molecular basis. We expect that such strategies will lead to the identification in the near future of critical neurulation genes, genes that when mutated perturb neurulation in a highly specific and predictable fashion and cause neurulation defects, thereby contributing to the formation of neural tubedefects. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:56:21