Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Constructional apraxia in Alzheimer's disease: Association with occipital lobe pathology and accelerated cognitive decline
Autore:
Smith, MZ; Esiri, MM; Barnetson, L; King, E; Nagy, Z;
Indirizzi:
Univ Oxford, OPTIMA, Dept Neuropathol, Oxford, England Univ Oxford Oxford England d, OPTIMA, Dept Neuropathol, Oxford, England Univ Oxford, OPTIMA, Dept Pharmacol, Oxford, England Univ Oxford Oxford England ord, OPTIMA, Dept Pharmacol, Oxford, England Univ Oxford, Dept Clin Neurol, Oxford, England Univ Oxford Oxford England iv Oxford, Dept Clin Neurol, Oxford, England
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 281 - 288
SICI:
1420-8008(200107/08)12:4<281:CAIADA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBRILLARY TANGLES; BALINTS SYNDROME; DEMENTIA; DEGENERATION; DURATION; SEVERITY; PLAQUES;
Keywords:
occipital lobe; constructional apraxia; Alzheimer's disease; amyloid; cognition; hyperphosphorylated tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nagy, Z Radcliffe Infirm, OPTIMA, NHS Trust, Woodstock Rd, Oxford OX2 6HE,England Radcliffe Infirm Woodstock Rd Oxford England OX2 6HE 6HE, England
Citazione:
M.Z. Smith et al., "Constructional apraxia in Alzheimer's disease: Association with occipital lobe pathology and accelerated cognitive decline", DEMENT G C, 12(4), 2001, pp. 281-288

Abstract

The functional impact and progression of occipital lobe pathology in sporadic late onset Alzheimer's disease (AD) is barely explored. It is accepted that the primary and association visual areas are affected relatively late,in the neocortical stages of AD. We analysed 60 prospectively assessed AD patients in whom global cognitive deterioration and constructional apraxia were evaluated longitudinally using the CAMDEX. Radioactive immunohistochemistry was used to assess the amount of AD-related pathology in Brodmann areas 18 and 17. Braak staging of each case was also carried out. This study showed that in AD patients constructional apraxia is associated with higher expression of hyperphosphorylated tau, Additionally our findings indicate that early constructional apraxia is a predictor of accelerated cognitive decline in AD. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:38:51