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Titolo:
Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
Autore:
Swainson, R; Hodges, JR; Galton, CJ; Semple, J; Michael, A; Dunn, BD; Iddon, JL; Robbins, TW; Sahakian, BJ;
Indirizzi:
Univ Cambridge, Dept Psychiat, Cambridge, England Univ Cambridge Cambridge England dge, Dept Psychiat, Cambridge, England Univ Cambridge, Dept Neurol, Cambridge, England Univ Cambridge CambridgeEngland ridge, Dept Neurol, Cambridge, England Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England SmithKline Beecham Ltd, Addenbrookes Ctr Clin Invest, Cambridge, England SmithKline Beecham Ltd Cambridge England lin Invest, Cambridge, England W Suffolk Hosp, Bury St Edmunds, Suffolk, England W Suffolk Hosp Bury St Edmunds Suffolk England Edmunds, Suffolk, England CeNeS Pharmaceut PLC, Cambridge, England CeNeS Pharmaceut PLC Cambridge England armaceut PLC, Cambridge, England
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 265 - 280
SICI:
1420-8008(200107/08)12:4<265:EDADDO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIANT FRONTOTEMPORAL DEMENTIA; MILD COGNITIVE IMPAIRMENT; PRECLINICAL PHASE; PARKINSONS-DISEASE; SEMANTIC DEMENTIA; FRONTAL VARIANT; TERM-MEMORY; PERFORMANCE; DYSFUNCTION; DEFICITS;
Keywords:
early detection; Alzheimer's disease; depression; neuropsychological assessment; differential diagnosis; neural and pharmacotherapeutic implications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Sahakian, BJ Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Box 189,Hills Rd, Cambridge CB2 2QQ, England Univ Cambridge Box 189,Hills Rd Cambridge England CB2 2QQ nd
Citazione:
R. Swainson et al., "Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks", DEMENT G C, 12(4), 2001, pp. 265-280

Abstract

The development of novel treatments for Alzheimer's disease (AD), aimed atameliorating symptoms and modifying disease processes, increases the need for early diagnosis. Neuropsychological deficits such as poor episodic memory are a consistent feature of early-in-the-course AD, but they overlap with the cognitive impairments in other disorders such as depression, making differential diagnosis difficult. Computerised and traditional tests of memory, attention and executive function were given to four subject groups: mild AD (n = 26); questionable dementia (QD; n = 43); major depression (n = 37) and healthy controls (n = 39), A visuo-spatial associative learning test accurately distinguished AD from depressed/control subjects and revealed anapparent subgroup of QD patients who performed like AD patients. QD patients' performance correlated with the degree of subsequent global cognitive decline. Elements of contextual and cued recall may account for the task's sensitivity and specificity for AD. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:05:56