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Titolo:
The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process
Autore:
Sjogren, M; Davidsson, P; Gottfries, J; Vanderstichele, H; Edman, A; Vanmechelen, E; Wallin, A; Blennow, K;
Indirizzi:
Univ Gothenburg, Sahlgrenska Hosp, Inst Clin Neurosci, Molndal, Sweden Univ Gothenburg Molndal Sweden osp, Inst Clin Neurosci, Molndal, Sweden AstraZeneca, Molndal, Sweden AstraZeneca Molndal SwedenAstraZeneca, Molndal, Sweden Innogenet, Ghent, Belgium Innogenet Ghent BelgiumInnogenet, Ghent, Belgium MRC, Stockholm, Sweden MRC Stockholm SwedenMRC, Stockholm, Sweden
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 257 - 264
SICI:
1420-8008(200107/08)12:4<257:TCFLOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; APOLIPOPROTEIN-E GENOTYPE; FRONTOTEMPORAL DEMENTIA; VASCULAR DEMENTIA; TRANSGENIC MICE; BETA-PROTEIN; NEURODEGENERATIVE DISEASES; TRANSPORTED PROTEINS; BIOCHEMICAL MARKER; CLINICAL-DIAGNOSIS;
Keywords:
Alzheimer's disease; frontotemporal dementia; vascular dementia; cerebrospinal fluid; tau protein; growth-associated protein-43; soluble amyloid precursor protein; beta-amyloid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Sjogren, M Inst Clin Neurosci, Psychiat Sect, SE-43180 Molndal, Sweden Inst Clin Neurosci Molndal Sweden SE-43180 80 Molndal, Sweden
Citazione:
M. Sjogren et al., "The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process", DEMENT G C, 12(4), 2001, pp. 257-264

Abstract

Cerebrospinal fluid (CSF) levels of tau (total tau), growth-associated protein-43 (GAP-43), soluble amyloid precursor protein (sAPP; i.e, total sAPP), and beta -amyloid(42) (A beta (42)) were studied in patients with frontotemporal dementia (FTD; n = 14), Alzheimer's disease (AD; n = 47) and vascular dementia (VAD; n = 16), and in age-matched controls (n = 12). CSF-tau was increased in AD compared to controls and FTD (p < 0.001 for both), CSF-GAP-43 was increased in AD compared to controls (p < 0.05), and both CSF-GAP-43 and CSF-sAPP were increased in AD compared to FTD (p < 0.01). Positive and highly significant correlations were found between CSF-tau and CSF-GAP-43 in all groups and between CSF-tau, CSF-GAP-43 and CSF-sAPP in AD. The correlations found may reflect a common pathophysiologic process such as axonal degeneration. Copyright (C) 2001 S. Karger AG. Basel.

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Documento generato il 26/01/20 alle ore 09:59:36