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Titolo:
Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease
Autore:
Davidsson, P; Bogdanovic, N; Lannfelt, L; Blennow, K;
Indirizzi:
Univ Gothenburg, Expt Neurosci Sect, Dept Clin Neurosci, SE-43180 Molndal,Sweden Univ Gothenburg Molndal Sweden SE-43180 eurosci, SE-43180 Molndal,Sweden Huddinge Hosp, KFC Novum, Geriatr Sect, Dept Clin Neurosci & Family Med, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 mily Med, S-14186 Huddinge, Sweden
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 243 - 250
SICI:
1420-8008(200107/08)12:4<243:REOAPP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; SYNAPTIC VESICLE PROTEIN; BETA-PROTEIN; NEUROFIBRILLARY TANGLES; RAT-BRAIN; CEREBROSPINAL-FLUID; NEURONAL EXPRESSION; DEMENTIA DISORDERS; TRANSGENIC MICE; SENILE PLAQUES;
Keywords:
amyloid precursor protein; Alzheimer's disease; cortical brain regions; immunoblotting; presenilin-1; rab3a;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Davidsson, P Univ Gothenburg, Expt Neurosci Sect, Dept Clin Neurosci, SE-43180 Molndal,Sweden Univ Gothenburg Molndal Sweden SE-43180 3180 Molndal,Sweden
Citazione:
P. Davidsson et al., "Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease", DEMENT G C, 12(4), 2001, pp. 243-250

Abstract

To study the role of amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD), the level of APP was analysed by quantitative immunoblotting in 6 AD patients and 6 age-matched controls in 9 brain regions. These were associative cortices (orbital frontal cortex, inferior temporal cortex, inferior parietal cortex), primary cortex (occipital cortex), limbic structures (anterior cingulate gyrus, hippocampus), subcortical structures (putamen, thalamus) and cerebellum. To assess a potential relationshipbetween APP and presenilin-1 (PS-1) and/or synaptic proteins, the levels of PS-1 and rab3a, a specific synaptic vesicle protein, were also determinedin the same tissue samples. The level of APP was almost the same in the association cortical regions, primary cortex, and limbic structures and in the subcortical structures, while the lowest level was found in the cerebellum. There were more marked differences in the level of PS-1 and rab3a between different brain regions. The highest levels of PS-1 and rab3a were found in the association cortical areas, while intermediate levels were found in primary cortex, limbic structures and subcortical structures. As for APP, the lowest level was found in cerebellum. We found significantly reduced levels of all three proteins in the association cortices and in hippocampus inAD. Our data show that the protein levels are reduced in specific areas, restricted to neuronal populations that are known to degenerate in AD. Due to the similarity of the expression of APP, PS-1 and rab3a, it is tempting to speculate whether there is a functional relationship between these proteins. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:30:05