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Titolo:
Mitochondria and the heart
Autore:
Hirano, M; Davidson, M; DiMauro, S;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Neurol, New York, NY 10032 USA
Titolo Testata:
CURRENT OPINION IN CARDIOLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 201 - 210
SICI:
0268-4705(200105)16:3<201:MATH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
KEARNS-SAYRE-SYNDROME; STROKE-LIKE EPISODES; MATERNALLY INHERITED CARDIOMYOPATHY; CYTOCHROME-C-OXIDASE; PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; ADENINE-NUCLEOTIDE TRANSLOCATOR; COMPLEX-I DEFICIENCY; LACTIC-ACIDOSIS; HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, M Columbia Univ, Coll Phys & Surg, Dept Neurol, P&S 4-443,630 W 168th St, New York, NY 10032 USA Columbia Univ P&S 4-443,630 W 168th St New York NY USA 10032 USA
Citazione:
M. Hirano et al., "Mitochondria and the heart", CURR OPIN C, 16(3), 2001, pp. 201-210

Abstract

Since the identification of the first pathogenic mutations of mitochondrial DNA in 1988, a plethora of information about human mitochondrial diseaseshas been brought to light. Not surprisingly, many of these disorders affect the myocardium, because this tissue relies heavily upon oxidative metabolism. This review focuses on disorders of the respiratory chain, the only area of mammalian cellular metabolism under the control of two genomes, nuclear and mitochondrial. Consequently, defects of aerobic synthesis of adenosine triphosphate (ATP) can be due to mutations of either genome. We describegenetic mitochondrial cardiomyopathies and briefly review mouse models andthe mitochondrial theory of presbycardia. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:37:04