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Titolo:
[18F]-FDG positron imaging in clinical management of lymphoma patients
Autore:
Talbot, JN; Haioun, C; Rain, JD; Meignan, M; Wioland, M; Misset, JL; Grahek, D; Kerrou, K; Montravers, F;
Indirizzi:
Assistance Publ Hop Paris, PET Ctr, Lymphoma Working Party, Paris, France Assistance Publ Hop Paris Paris France oma Working Party, Paris, France Assistance Publ Hop Paris, Hop Tenon, Nucl Med Serv, F-75020 Paris, FranceAssistance Publ Hop Paris Paris France F-75020 rv, F-75020 Paris, France Hop Henri Mondor, Serv Hematol, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 Hematol, F-94010 Creteil, France Hop St Louis, Nucl Med Serv, Paris, France Hop St Louis Paris FranceHop St Louis, Nucl Med Serv, Paris, France Hop Henri Mondor, Nucl Med Serv, F-94010 Creteil, France Hop Henri MondorCreteil France F-94010 ed Serv, F-94010 Creteil, France Hop Armand Trousseau, Unite Med Nucl, Paris, France Hop Armand Trousseau Paris France usseau, Unite Med Nucl, Paris, France Hop Paul Brousse, Serv Cancerol, Villejuif, France Hop Paul Brousse Villejuif France sse, Serv Cancerol, Villejuif, France
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 3, volume: 38, anno: 2001,
pagine: 193 - 221
SICI:
1040-8428(200106)38:3<193:[PIICM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; EMISSION-TOMOGRAPHY PET; FDG-PET; MALIGNANT-LYMPHOMA; F-18 FLUORODEOXYGLUCOSE; COMPUTED-TOMOGRAPHY; BONE-MARROW; DISEASE; FLUORINE-18-FLUORODEOXYGLUCOSE; 2--FLUORO-2-DEOXY-D-GLUCOSE;
Keywords:
children; [18F]-fluoro deoxy glucose; follow-up of chemotherapy; lymphoma; positron emission tomography;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Talbot, JN Assistance Publ Hop Paris, PET Ctr, Lymphoma Working Party, Paris, France Assistance Publ Hop Paris Paris France Party, Paris, France
Citazione:
J.N. Talbot et al., "[18F]-FDG positron imaging in clinical management of lymphoma patients", CR R ONC H, 38(3), 2001, pp. 193-221

Abstract

[18F]-FDG is a glucose analogue labelled with a short-lived positron emitter. During the past decade, it has been proposed to detect in vivo lymphomalesions with PET, a new non-invasive imaging modality. We aimed at reviewing the current experience with FDG in several clinical settings of lymphoma. Due to the lack of specificity of FDG for lymphoma, histology remains compulsory to establish the diagnosis. Nevertheless, in the case of AIDS, FDG imaging has been proposed to differentiate lymphoma and opportunistic infections in brain lesions. To explore lymphoma extension, FDG-PET highlights more lesions than CT or the clinical examination and results in upstaging 13% of cases. It could also be used for selecting a site for biopsy when the location considered first clinically is difficult to access. Staging lymphoma with FDG-PET also provides baseline images for subsequent evaluation of therapy, which is one of the most promising indications: a negative scan predicts response to therapy and subsequent remission with a predictive valueof 89%, and a positive scan either reflects resistance or predicts relapsewith a predictive value of 83%. The current achievement of FDG imaging is the early detection of recurrence or of viable tissue in residual masses that remain several months after treatment. Both its sensitivity (84%) and its specificity (95%) overwhelm the values of conventional imaging, mainly CTand gallium-67 scintigraphy. When PET, as a new clinical imaging modality,is not yet widely demanded by clinicians and/or the number of FDG examinations is less than 500 per year, a 'hybrid' gamma-camera or CDET can be an alternative to dedicated PET. For 3 years, we have been using FDG-CDET in the 2D mode without attenuation correction, and obtained the following accuracy in a total of 40 examinations that could be evaluated: 85% for assessment of chemotherapy and 92% to detect recurrences and evaluate residual masses. Our preliminary results also stress the interest in FDG examination in childhood lymphoma, with the same indications as in adults. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:00:26