Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The prehospital treatment of status epilepticus (PHTSE) study: Design and methodology
Autore:
Lowenstein, DH; Alldredge, BK; Allen, F; Neuhaus, J; Corry, M; Gottwald, M; ONeil, N; Ulrich, S; Isaacs, SM; Gelb, A;
Indirizzi:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Clin Pharm, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, San Francisco Gen Hosp, Dept Emergency Serv, SanFrancisco, CA USA Univ Calif San Francisco San Francisco CA USA Serv, SanFrancisco, CA USA Carondalet Hlth Network, Tucson, AZ USA Carondalet Hlth Network Tucson AZUSA dalet Hlth Network, Tucson, AZ USA San Francisco Fire Dept, Paramed Div, San Francisco, CA USA San Francisco Fire Dept San Francisco CA USA Div, San Francisco, CA USA Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
CONTROLLED CLINICAL TRIALS
fascicolo: 3, volume: 22, anno: 2001,
pagine: 290 - 309
SICI:
0197-2456(200106)22:3<290:TPTOSE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LORAZEPAM; DIAZEPAM;
Keywords:
Status epilepticus; emergency medical services; benzodiazepines; diazepam; lorazepam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Lowenstein, DH Harvard Univ, Sch Med, Gordon Hall,Room 103,25 Shattuck St,Boston, MA 02115 USA Harvard Univ Gordon Hall,Room 103,25 Shattuck St Boston MA USA 02115
Citazione:
D.H. Lowenstein et al., "The prehospital treatment of status epilepticus (PHTSE) study: Design and methodology", CONTR CL TR, 22(3), 2001, pp. 290-309

Abstract

Status epilepticus is a neurological emergency that is typically first encountered and managed in the prehospital environment. Although aggressive pharmacological treatment of status epilepticus is well established in the emergency department and hospital settings, the relative risks and benefits of active therapy for status epilepticus in the prehospital setting are not known. The Prehospital Treatment of Status Epilepticus (PHTSE) study is a prospective, randomized, double-blind, placebo-controlled study designed to address the following aims: (1) to determine whether administration of benzodiazepines by paramedics is an effective and safe means of treating statusepilepticus in the prehospital setting and whether this therapy influenceslonger-term patient outcome, (2) to determine whether lorazepam is superior to diazepam for the treatment of status epilepticus in the prehospital setting, and (3) to determine whether control of status epilepticus prior to arrival to the emergency department influences patient disposition. The initial phase of the PHTSE study began in January 1994 and was completed in February 1999 after the successful enrollment of 205 patients into the three treatment arms. In this paper, we describe the rationale for the conceptualization of the study and details of the study design and methodology, and emphasize some aspects of study implementation that are unique to research involving the emergency medical system. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:39:53