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Titolo:
Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature male chickens (Gallus domesticus)
Autore:
Stanton, BJ; El-Sabeawy, F; Yang, XF; Enan, E; Lasley, BL;
Indirizzi:
Univ Calif Davis, Inst Toxicol & Environm Hlth, Lasley Lab, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Hlth, Lasley Lab, Davis, CA 95616 USA Vanderbilt Univ, Med Ctr, Dept Biochem, Nashville, TN USA Vanderbilt UnivNashville TN USA ed Ctr, Dept Biochem, Nashville, TN USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 129, anno: 2001,
pagine: 35 - 47
SICI:
1532-0456(200105)129:1<35:IOEA2(>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE ACTIVITY; ENZYME-IMMUNOASSAY; ADIPOSE TISSUES; MESSENGER-RNA; FEMALE RATS; ESTRADIOL; RECEPTOR; TESTOSTERONE; TOXICITY; BINDING;
Keywords:
adipose; avian; chicken; estrogen; lipoprotein lipase; liver; TCDD; wasting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Stanton, BJ Univ Calif Davis, Inst Toxicol & Environm Hlth, Lasley Lab, 1 Shields Ave,Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA95616 CA 95616 USA
Citazione:
B.J. Stanton et al., "Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature male chickens (Gallus domesticus)", COMP BIOC C, 129(1), 2001, pp. 35-47

Abstract

The interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and estrogenwas studied in chickens to more dearly define this relationship in an avian species and its role in the enhanced sensitivity of female chickens to TCDD-induced wasting syndrome. Twenty male chickens (7-9 weeks old) were divided evenly into four groups: control (CTL, received the same volume of vehicle); estrogen-treated (E2, 1 mg/kg estradiol cypionate injections on days 1, 2 and 3); TCDD-treated (TCDD, single 50 mug/kg injection on day 4); and estrogen plus TCDD (E2 + TCDD, as above), with measurements taken on day 14. The E2 group compared with the CTL group had decreased comb height (24%),comb length (26%) and adipose tissue (AT) lipoprotein lipase (LPL) activity relative to AT mass (51%), while liver mass and body weight gain were each increased by 28%. The TCDD group had increased liver mass (62%), reduced comb length (17%), and reduced AT LPL activity indexed to AT mass (70%) compared with the CTL group. Finally, the E2 + TCDD group had 37% lower body weight gain and 30% larger livers relative to body mass compared with the E2group, but were not significantly different from the TCDD group. These data show that TCDD antagonized several effects of exogenous estrogen in male chickens, while estrogen enhanced TCDD toxicity in a tissue-specific manner. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:43:53