Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regulation of surfactant secretion
Autore:
Rooney, SA;
Indirizzi:
Yale Univ, Sch Med, Dept Pediat, Div Perinatal Med, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 v Perinatal Med, New Haven, CT 06520 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 129, anno: 2001,
pagine: 233 - 243
SICI:
1095-6433(200105)129:1<233:ROSS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SUSTAINED CELLULAR-RESPONSES; BETA-ADRENERGIC RECEPTORS; ADP-RIBOSYLATION-FACTOR; MESSENGER-RNA LEVELS; II CELLS; PULMONARY SURFACTANT; LUNG SURFACTANT; EPITHELIAL-CELLS; PRIMARY CULTURES;
Keywords:
lung surfactant; secretion; signal transduction; type 11 pneumocyte; protein kinase; phospholipase D; phospholipase; C-beta 3; P2Y(2) receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Rooney, SA Yale Univ, Sch Med, Dept Pediat, Div Perinatal Med, POB 208064,New Haven,CT 06520 USA Yale Univ POB 208064 New Haven CT USA 06520 Haven,CT 06520 USA
Citazione:
S.A. Rooney, "Regulation of surfactant secretion", COMP BIOC A, 129(1), 2001, pp. 233-243

Abstract

Lung surfactant is synthesized in the alveolar type II cell. Its lipids and hydrophobic proteins (SP-B and SP-C) are stored in lamellar bodies and secreted by regulated exocytosis. In contrast, the hydrophilic proteins (SP-Aand SP-D) appear to be secreted independently of lamellar bodies. Regulation of surfactant secretion is mediated by at least three distinct signalingmechanisms: activation of adenylate cyclase with formation of cAMP and activation of cAMP-dependent protein kinase; activation of protein kinase C; and a Ca2+-regulated mechanism that likely results in the activation of Ca2+-calmodulin-dependent protein kinase. These signaling mechanisms are activated by a variety of agonists, some of which may have a physiological role. ATP is one such agent and it activates all three signaling mechanisms. There is increasing information on the identity of several of the signaling proteins involved in surfactant secretion although others remain to be established. In particular the identity of the phospholipase C, protein kinase C and phospholipase D isomers expressed in the type II cell and/or involved insurfactant secretion has been established. Distal steps in the secretory pathway beyond protein kinase activation as well as the physiological regulation of surfactant secretion, are major issues that need to be addressed. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:51:47