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Titolo:
The conception of fusion pores as rate-limiting structures for surfactant secretion
Autore:
Haller, T; Pfaller, K; Dietl, P;
Indirizzi:
Innsbruck Univ, Dept Physiol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ysiol, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Anat & Histol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 istol, A-6020 Innsbruck, Austria
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 129, anno: 2001,
pagine: 227 - 231
SICI:
1095-6433(200105)129:1<227:TCOFPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
II CELLS; EXOCYTOTIC FUSION; LUNG SURFACTANT; VESICLE FUSION; PHOSPHATIDYLCHOLINE SECRETION; ACTIN DEPOLYMERIZATION; SIGNAL-TRANSDUCTION; EPITHELIAL-CELLS; RELEASE; MECHANISMS;
Keywords:
alveolus; exocytosis; fusion pores; lamellar body; lung; pulmonary; secretion; surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Haller, T Innsbruck Univ, Dept Physiol, Fritz Pregl Str 3, A-6020 Innsbruck, Austria Innsbruck Univ Fritz Pregl Str 3 Innsbruck Austria A-6020 stria
Citazione:
T. Haller et al., "The conception of fusion pores as rate-limiting structures for surfactant secretion", COMP BIOC A, 129(1), 2001, pp. 227-231

Abstract

It is well established that the release of surfactant phospholipids into the alveolar lumen proceeds by the exocytosis of lamellar bodies (LBs), the characteristic storage organelles of surfactant in alveolar type It cells. Consequently, the fusion of LBs with the plasma membrane and the formation of exocytotic fusion pores are key steps linking cellular synthesis of surfactant with its delivery into the alveolar space. Considering the unique structural organization of LBs or LB-associated aggregates which are found inlung lavages, and the roughly 1-mum-sized dimensions of these particles. we speculated whether the fusion pore diameter of fused LBs might be a specific hindrance for surfactant secretion, delaying or even impeding full release. In this mini-review, we have compiled published data shedding light ona possibly important role of fusion pores during the secretory process in alveolar type II cells. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:46:01