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Titolo:
Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance
Autore:
Bourbon, JR; Chailley-Heu, B;
Indirizzi:
Univ Paris 07, INSERM Unite 319, F-75251 Paris 05, France Univ Paris 07 Paris France 05 INSERM Unite 319, F-75251 Paris 05, France
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 129, anno: 2001,
pagine: 151 - 161
SICI:
1095-6433(200105)129:1<151:SPITDT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERTEBRATE PULMONARY SURFACTANT; A-DEFICIENT MICE; LAMELLAR BODIES; BOUNDARY LUBRICATION; EUSTACHIAN-TUBE; D EXPRESSION; MIDDLE-EAR; IN-VIVO; RAT; MESOTHELIUM;
Keywords:
surfactant proteins; lung; gut; mesothelial tissues; evolution; non-mammals; fish; host defence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Bourbon, JR Univ Paris 07, INSERM Unite 319, 2 Pl Jussieu, F-75251 Paris 05, France Univ Paris 07 2 Pl Jussieu Paris France 05 1 Paris 05, France
Citazione:
J.R. Bourbon e B. Chailley-Heu, "Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance", COMP BIOC A, 129(1), 2001, pp. 151-161

Abstract

For years, the so-called surfactant proteins (SPs) that were discovered inthe phospholipid-rich material designated pulmonary surfactant, were considered to be lung-specific. The fact that surfactant-like materials composedof phospholipids are secreted by a number of other organs recently prompted several groups to search for SP expression in these organs also. The hydrophilic proteins SP-A and SP-D and their transcripts have been found in a number of tissues, including gastric and intestinal mucosae, mesothelial tissues (mesentery, peritoneum, and pleural), synovial cells, Eustachian tube and sinus. and possibly in salivary glands, pancreas, and urinary tract. Bycontrast, the hydrophobic proteins SP-B and SP-C actually appear to be expressed in lung epithelium only. SP-A and SP-D belong to the innate defence system against pathogens and play a role as opsonins for facilitating phagocytosis. Their expression appears as a general feature of organs exposed topathogens because they present an interface with the external milieu. Although this function has thus far been investigated in the lung only through the gene-targeting approach, increased expression of SP-A in the infected middle ear and of SP-D in the Helicobacter-infected antrum argues for such afunction also in other organs. In organs that are not exposed to external pathogens, their role is likely to exert anti-inflammatory and immunomodulatory functions, as suggested by increased SP-A immunoreactivity in rheumatoid disease. SP-A and SP-B have been found in association with phospholipidsin the lung of all air-breathing vertebrates, including the most primitiveforms represented by lungfish. which implies that the surfactant system had a single evolutionary origin. Immunochemical proximity of the proteins among vertebrates indicates considerable conservation during evolution. Moreover, the finding of an SP-A-like protein in intestine and swim bladder of actinopterygian fish implies that the ancestral form of the protein was already present before the emergence of lung structures. (C) 2001 Elsevier Science Inc. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 13:58:17