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Titolo:
Bilayer fragments and bilayered micelles (bicelles) of dimyristoylphosphatidylglycerol (DMPG) are induced by storage in distilled water at 4 degrees C
Autore:
Meyer, HW; Richter, W; Rettig, W; Stumpf, M;
Indirizzi:
Klinikum Friedrich Schiller Univ Jena, Inst Ultrastrukt Forschung, D-07743Jena, Germany Klinikum Friedrich Schiller Univ Jena Jena Germany D-07743 Jena, Germany Univ Halle Wittenberg, Inst Pharmaceut Chem, D-06120 Halle, Germany Univ Halle Wittenberg Halle Germany D-06120 Chem, D-06120 Halle, Germany
Titolo Testata:
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
, volume: 183, anno: 2001,
pagine: 495 - 504
SICI:
0927-7757(20010715)183:<495:BFABM(>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERMOTROPIC BEHAVIOR; ELECTRON-MICROSCOPY; PHASE; PHOSPHATIDYLGLYCEROL; CURVATURES; FUSION;
Keywords:
bicelles; dimyristoylphosphatidylglycerol; freeze-fracture; electron microscopy; phase transitions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, HW Klinikum Friedrich Schiller Univ Jena, Inst Ultrastrukt Forschung, Ziegelmuhlenweg 1, D-07743 Jena, Germany Klinikum Friedrich Schiller Univ Jena Ziegelmuhlenweg 1 Jena Germany D-07743
Citazione:
H.W. Meyer et al., "Bilayer fragments and bilayered micelles (bicelles) of dimyristoylphosphatidylglycerol (DMPG) are induced by storage in distilled water at 4 degrees C", COLL SURF A, 183, 2001, pp. 495-504

Abstract

Hydration of the anionic lipid DMPG with distilled water and storage at similar to4 degreesC results in a disintegration of bilayers into fragments of different sizes and bicelles with a diameter of similar to 50 nm. Tightlypacked multilamellar aggregates are not observed under these conditions, which are otherwise formed during cold-storage after hydration at a certain ionic strength and in the presence of Na+, with a characteristic phase transition at similar to 40 degreesC. The bilayer fragments are able to form ripples after heating to a temperature between similar to 17 and 25 degreesC,and the larger ones form vesicles after heating to 30 degreesC. Differential scanning calorimetry of samples containing predominantly fragments reveals pretransition and main transition peaks in agreement with the morphological observations, plus an additional subtransition peak at similar to 12 degreesC. No low-temperature subtransition peak exists if the sample containspredominantly bicelles. The bicelles form neither ripples nor vesicles upon heating to higher temperatures, and consequently the DSC scan and rescan are largely identical with transitions at similar to 21, 27 and 28.4 degreesC. To explain these three melting transitions, a partial chain interdigitation at the rim of the bicelles is discussed. Bicelles and fragments are also formed by mixtures of DMPG with DMPC. (C) 2001 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 01:37:44