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Titolo:
Immunopathogenesis of human immunodeficiency virus: Implications for immune-based therapies
Autore:
Sereti, I; Lane, HC;
Indirizzi:
NIAID, Cellular & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 mmunoregulat Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 12, volume: 32, anno: 2001,
pagine: 1738 - 1755
SICI:
1058-4838(20010615)32:12<1738:IOHIVI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; COLONY-STIMULATING FACTOR; PLACEBO-CONTROLLED TRIAL; CYTOTOXIC T-LYMPHOCYTES; HIV-INFECTED PATIENTS; RANDOMIZED CONTROLLED TRIAL; CD4 CELL COUNTS; RECOMBINANT HUMAN INTERLEUKIN-12; SUSTAINED VIRAL SUPPRESSION; PHASE-I TRIAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
158
Recensione:
Indirizzi per estratti:
Indirizzo: Lane, HC NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bldg 10,Rm 11S-231,10 Ctr Dr,MSC 1876, Bethesda, MD 20892 USA NIAID Bldg 10,Rm 11S-231,10 Ctr Dr,MSC 1876 Bethesda MD USA 20892
Citazione:
I. Sereti e H.C. Lane, "Immunopathogenesis of human immunodeficiency virus: Implications for immune-based therapies", CLIN INF D, 32(12), 2001, pp. 1738-1755

Abstract

Human immunodeficiency virus (HIV) infection leads to a state of CD4 lymphopenia and generalized immune activation with subsequent development of opportunistic infections and neoplasms. The use of highly active antiretroviral treatment has dramatically improved the clinical outcome for HIV-infectedpatients, but the associated cost and toxicity and the eventual development of drug resistance have underscored the need for additional therapeutic strategies. Immune-based therapies, such as treatment with cytokines or immunosuppressants, adoptive immunotherapy, and therapeutic immunizations, are being intensely investigated as potential supplements to antiretroviral therapy. Although much data have been generated as a result of these efforts, to date there has been little evidence of the clinical efficacy of these strategies. Randomized clinical studies remain critical in evaluating the clinical significance and the role of immune-based therapies in the therapeutic armamentarium against HIV.

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Documento generato il 07/04/20 alle ore 04:13:45