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Titolo:
Cell therapy and transplantation in Parkinson's disease
Autore:
Lindvall, O; Hagell, P;
Indirizzi:
Univ Lund Hosp, Wallenberg Neurosci Ctr BMC A11, Sect Restorat Neurol, S-22184 Lund, Sweden Univ Lund Hosp Lund Sweden S-22184 Restorat Neurol, S-22184 Lund, Sweden
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 356 - 361
SICI:
1434-6621(200104)39:4<356:CTATIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL DOPAMINE NEURONS; EMBRYONIC MESENCEPHALIC NEURONS; LONG-TERM SURVIVAL; NIGRAL TRANSPLANTATION; PUTAMINAL IMPLANTS; LAZAROIDS IMPROVE; PROGENITOR CELLS; GRAFT-SURVIVAL; STEM-CELLS; PATIENT;
Keywords:
Parkinson's disease; neural transplantation; substantia nigra; positron emission tomography; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lindvall, O Univ Lund Hosp, Wallenberg Neurosci Ctr BMC A11, Sect RestoratNeurol, S-22184 Lund, Sweden Univ Lund Hosp Lund Sweden S-22184 rol, S-22184 Lund, Sweden
Citazione:
O. Lindvall e P. Hagell, "Cell therapy and transplantation in Parkinson's disease", CLIN CH L M, 39(4), 2001, pp. 356-361

Abstract

Transplanted human fetal dopamine neurons can reinnervate the striatum in patients with Parkinson's disease (PD). Recent findings using positron emission tomography indicate that the grafts are functionally integrated and restore dopamine release in the patient's striatum. The grafts can exhibit long-term survival without immunological rejection and despite an ongoing disease process and continuous antiparkinsonian drug treatment. In the most successful cases, patients have been able to withdraw L-dopa treatment after transplantation and resume an independent life. About two-thirds of graftedpatients have shown clinically useful, partial recovery of motor function. The major obstacle for the further development of this cell replacement strategy is that large amounts of human fetal mesencephalic tissue are neededfor therapeutic effects. Stem cells hold promise as a virtually unlimited source of self-renewing progenitors for transplantation. The possibility togenerate dopamine neurons from such cells is now being explored using different approaches. However, so far the generated neurons have survived poorly after transplantation in animals.

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Documento generato il 21/01/20 alle ore 01:51:53