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Titolo:
Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease
Autore:
Topic, E; Simundic, AM; Stefanovic, M; Demarin, V; Vukovic, V; Lovrencic-Husjan, A; Zuntar, I;
Indirizzi:
Sestre Milosrdnice Univ Hosp, Inst Clin Chem, Zagreb 10000, Croatia SestreMilosrdnice Univ Hosp Zagreb Croatia 10000 Zagreb 10000, Croatia Univ Zagreb, Sch Med, Inst Clin Chem, Zagreb 41001, Croatia Univ Zagreb Zagreb Croatia 41001 , Inst Clin Chem, Zagreb 41001, Croatia Univ Zagreb, Sch Med, Univ Dept Neurol, Zagreb 41001, Croatia Univ ZagrebZagreb Croatia 41001 Univ Dept Neurol, Zagreb 41001, Croatia Univ Zagreb, Sch Pharm & Med Biochem, Dept Analyt Chem, Zagreb 41000, Croatia Univ Zagreb Zagreb Croatia 41000 Dept Analyt Chem, Zagreb 41000, Croatia
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 346 - 350
SICI:
1434-6621(200104)39:4<346:POAE(M>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E POLYMORPHISM; CORONARY-ARTERY DISEASE; LOW-DENSITY-LIPOPROTEIN; PLASMA HOMOCYSTEINE; SERUM PARAOXONASE; VASCULAR-DISEASE; WALL THICKNESS; RISK FACTOR; ATHEROSCLEROSIS; STROKE;
Keywords:
apoprotein E (APOE); methylenetetrahydrofolate (MTHFR); paraoxonase (PON1); PCR-RFLP; stroke; carotid stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Topic, E Sestre Milosrdnice Univ Hosp, Inst Clin Chem, Vinogradska C 29, Zagreb 10000, Croatia Sestre Milosrdnice Univ Hosp Vinogradska C 29 Zagreb Croatia 10000
Citazione:
E. Topic et al., "Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease", CLIN CH L M, 39(4), 2001, pp. 346-350

Abstract

Although controversial, data on the genetic polymorphism of apoprotein E (APOE), methylenetetrahydrofolate (MTHFR) and paraoxonase (PON1) genes implicate their role in the development of cerebrovascular disease. The aim of this study was to assess the association of polymorphism of APOE, MTHFR and PON1 genes in 56 stroke and 36 carotid stenosis patients, and in 124 control subjects by PCR-restriction fragment length polymorphism analysis. In the stroke group a significantly different MTHFR genotype distribution (p=0.004, odds ratio for T/T of 17.571), but no significant difference in APOE and PON1 allele and genotype distribution compared to the control was found. The carotid stenosis group exhibited a significantly different APOE allele and genotype distribution (p=0.023, odds ratio APOE epsilon3 epsilon4of 4.24), but no significant difference in the MTHFR and PON1 allele and genotype distribution from the control group. The preliminary results obtained in this study revealed an association of the MTHFR and APOE gene polymorphism with cerebrovascular disease, suggesting a significant risk for stroke in subjects who are homozygous for the T allele and for carotid stenosis in subjects having APOE epsilon3 epsilon4 genotype. Additional studies in larger patient groups are needed to confirm these observations.

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Documento generato il 29/03/20 alle ore 00:12:46