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Titolo:
Source of endothelin-1 in subarachnoid hemorrhage
Autore:
Bertsch, T; Kuehl, S; Muehlhauser, F; Walter, S; Hodapp, B; Rossol, S; Schmeck, J; Ragoschke, A; Schutt, S; Fritzinger, M; Horn, P; Vajkoczy, P; Wendel-Wellner, M; Fassbender, K;
Indirizzi:
Univ Heidelberg, Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 urol, D-68135 Mannheim, Germany Univ Heidelberg, Clin Mannheim, Dept Clin Chem, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 Chem, D-68135 Mannheim, Germany Univ Heidelberg, Clin Mannheim, Dept Internal Med, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 Med, D-68135 Mannheim, Germany Univ Heidelberg, Clin Mannheim, Dept Anesthesiol, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 siol, D-68135 Mannheim, Germany Univ Heidelberg, Clin Mannheim, Dept Neurosurg, D-68135 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68135 surg, D-68135 Mannheim, Germany
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 341 - 345
SICI:
1434-6621(200104)39:4<341:SOEISH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE CEREBRAL-ARTERIES; CEREBROSPINAL-FLUID; PLASMA ENDOTHELIN; VASOSPASM; CELLS; BIOSYNTHESIS; MECHANISM; PROGRESS; PEPTIDE; MODEL;
Keywords:
subarachnoidal hemorrhage; endothelin-1; vasospasm; cerebral ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fassbender, K Univ Heidelberg, Clin Mannheim, Dept Neurol, Theodor Kutzer Ufer, D-68135 Mannheim, Germany Univ Heidelberg Theodor Kutzer Ufer Mannheim Germany D-68135
Citazione:
T. Bertsch et al., "Source of endothelin-1 in subarachnoid hemorrhage", CLIN CH L M, 39(4), 2001, pp. 341-345

Abstract

Endothelin-1 is the most potent vasoconstrictor known to date. This peptide is believed to play a pathophysiological role in the development of vasospasm, the most important complication of subarachnoid hemorrhage (SAH). In the present study we investigated the release of endothelin-1 in SAH and analyzed the cellular source of this peptide. At a protein and mRNA level we were able to show that endothelin-1 is produced by mononuclear leukocytes. Complementary in vitro studies revealed that aging and subsequent hemolysisof blood is sufficient to induce production of endothelin-1 by mononuclearleukocytes. Thus, cerebrospinal fluid-derived mononuclear leukocytes are asource of endothelin-1 in patients suffering from SAH. This finding may have important therapeutic implications as anti-leukocyte strategies could prevent cerebrovascular complications in SAH patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:18:14