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Titolo:
The intrathecal humoral immune response: Laboratory analysis and clinical relevance
Autore:
Sindic, CJM; Van Antwerpen, MP; Goffette, S;
Indirizzi:
Univ Catholique Louvain, Lab Neurochim, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Clin Univ St Luc, B-1200 Brussels, Belgium Clin Univ St Luc Brussels Belgium B-1200 t Luc, B-1200 Brussels, Belgium
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 333 - 340
SICI:
1434-6621(200104)39:4<333:TIHIRL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; HERPES-SIMPLEX ENCEPHALITIS; CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CEREBROSPINAL-FLUID CSF; MEDIATED CAPILLARY BLOT; MULTIPLE-SCLEROSIS; TUBERCULOUS MENINGITIS; NEUROLOGICAL DISEASES; CONSENSUS REPORT;
Keywords:
immunity, intrathecal; cerebrospinal fluid; immunoglobulins; multiple sclerosis; infectious diseases; nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sindic, CJM Univ Catholique Louvain, Lab Neurochim, 53-59 Ave Mounier, B-1200 Brussels, Belgium Univ Catholique Louvain 53-59 Ave Mounier Brussels Belgium B-1200
Citazione:
C.J.M. Sindic et al., "The intrathecal humoral immune response: Laboratory analysis and clinical relevance", CLIN CH L M, 39(4), 2001, pp. 333-340

Abstract

In normal conditions, albumin and immunoglobulin (Ig)G in the cerebrospinal fluid (CSF) originate from the blood, and there is no antibody productionwithin the central nervous system. Up to 20% of CSF proteins are intrathecally synthesized, but the major fraction is blood-derived. The CSF/serum albumin quotient (Q(Alb)) is the best marker of the blood-CSF barrier function. The corresponding immunoglobulin quotients (Q(IGG), Q(IGA), Q(IGM)) are not linearly related to Q(Alb) and their correlations are defined by an hyperbolic equation. This equation is used to discriminate between a blood-derived and a locally produced fraction of immunoglobulins in case of an intrathecal humoral immune response. The detection of CSF-specific oligoclonal IgG is more sensitive than the quantitative comparison between Q(IGG) and Q(Alb). A further step is the determination of antibody indices and the detection of specific oligoclonal antibodies by antigen-driven immunoblots. CSF analysis remains a cornerstone for the diagnosis of various neurological disorders, including multiple sclerosis and infectious diseases of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:40:23