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Titolo:
Reporting cerebrospinal fluid data: Knowledge base and interpretation software
Autore:
Reiber, H; Otto, M; Trendelenburg, C; Wormek, A;
Indirizzi:
Univ Gottingen, Neurol Klin, Neurochem Lab, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Lab, D-37075 Gottingen, Germany Stadt Kliniken, Inst Lab Med, Frankfurt, Germany Stadt Kliniken Frankfurt Germany iken, Inst Lab Med, Frankfurt, Germany ESL Wormek, Software Solut Med, Gerbrunn, Germany ESL Wormek Gerbrunn Germany rmek, Software Solut Med, Gerbrunn, Germany
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 324 - 332
SICI:
1434-6621(200104)39:4<324:RCFDKB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; CENTRAL-NERVOUS-SYSTEM; NEURON-SPECIFIC ENOLASE; MULTIPLE-SCLEROSIS; NEUROLOGICAL DISEASES; INTRATHECAL SYNTHESIS; CONSENSUS REPORT; IGG SYNTHESIS; TAU-PROTEIN; DIAGNOSIS;
Keywords:
cerebrospinal fluid; interpretation software; neurological diseases; software;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Reiber, H Univ Gottingen, Neurol Klin, Neurochem Lab, Robert Koch Str 40, D-37075 Gottingen, Germany Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075 any
Citazione:
H. Reiber et al., "Reporting cerebrospinal fluid data: Knowledge base and interpretation software", CLIN CH L M, 39(4), 2001, pp. 324-332

Abstract

The compilation of cerebrospinal fluid (CSF) patient data together with a graphic display of immunoglobulin patterns in a single CSF report has two main advantages: analytical and clinical plausibility control of a complex set of data improves quality assessment and allows improved clinical specificity and sensitivity for recognition of disease-related "typical" data patterns. The widespread use of automated on-line evaluation programs can now be combined with knowledge-based programs for interpretation by clinical chemists and neurologists. These programs are based on knowledge of neuroimmunology, blood-CSF barrier function and dysfunction, influence of CSF flow onconcentrations of blood-derived and brain-derived proteins in CSF, specific intrathecal antibody synthesis and relevance of brain proteins for differential diagnosis of degenerative diseases. The relevance of hyperbolic discrimination functions in quotient diagrams for the detection of intrathecal immunoglobulin synthesis is compared with earlier, still frequently used, linear interpretation functions. Differences found in commercially availableinterpretation software are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:34:41