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Titolo:
Caspase-3 apoptotic signaling following injury to the central nervous system
Autore:
Springer, JE; Nottingham, SA; McEwen, ML; Azbill, RD; Jin, Y;
Indirizzi:
Univ Kentucky, Med Ctr, Dept Anat & Neurobiol, Ctr Spinal Cord & Head Injury Res, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Injury Res, Lexington, KY 40536 USA
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 299 - 307
SICI:
1434-6621(200104)39:4<299:CASFIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD INJURY; TRAUMATIC BRAIN INJURY; PROGRAMMED CELL-DEATH; CYTOCHROME-C RELEASE; WD-40 REPEAT REGION; CAENORHABDITIS-ELEGANS; NEURONAL APOPTOSIS; CEREBRAL-ISCHEMIA; IN-VIVO; CYSTEINE PROTEASE;
Keywords:
caspases; apoptosis; spinal cord trauma; brain trauma;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Springer, JE Univ Kentucky, Med Ctr, Dept Anat & Neurobiol, Ctr Spinal Cord & Head Injury Res, 800 Rose St, Lexington, KY 40536 USA Univ Kentucky 800Rose St Lexington KY USA 40536 KY 40536 USA
Citazione:
J.E. Springer et al., "Caspase-3 apoptotic signaling following injury to the central nervous system", CLIN CH L M, 39(4), 2001, pp. 299-307

Abstract

Apoptotic cell death is a fundamental and highly regulated biological process in which a cell is instructed to participate actively in its own demise. This process of cellular suicide is activated by developmental and environmental cues and normally plays an essential role in eliminating superfluous, damaged, and senescent cells of many tissue types. In recent years, a number of experimental studies have provided evidence of widespread neuronal and glial apoptosis following injury to the central nervous system (CNS). These studies indicate that injury-induced apoptosis can be detected from hours to days following injury and may contribute to neurological dysfunction. Given these findings, understanding the biochemical signaling events controlling apoptosis is a first step towards developing therapeutic agents which would target this cell death process. This review will focus on the molecular cell death pathways responsible for generating the apoptotic phenotype, summarize what is currently known about apoptotic signals activated in the injured CNS, and what potential strategies might be pursued to reduce this cell death process as a means to promote functional recovery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:23:16