Catalogo Articoli (Spogli Riviste)

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Titolo:
Dynamic aspects of platelet adhesion under flow
Autore:
Dopheide, SM; Yap, CL; Jackson, SP;
Indirizzi:
Box Hill Hosp, Monash Med Sch, Australian Ctr Blood Dis, Dept Med, Box Hill, Vic 3128, Australia Box Hill Hosp Box Hill Vic Australia 3128 , Box Hill, Vic 3128, Australia Box Hill Hosp, Dept Pathol, Box Hill, Vic 3128, Australia Box Hill Hosp Box Hill Vic Australia 3128 , Box Hill, Vic 3128, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 5-6, volume: 28, anno: 2001,
pagine: 355 - 363
SICI:
0305-1870(200105/06)28:5-6<355:DAOPAU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; GLYCOPROTEIN-IIB-IIIA; PROTEIN-KINASE-C; VONWILLEBRAND-FACTOR BINDING; COLLAGEN-LIKE PEPTIDES; HUMAN BLOOD-PLATELETS; RECEPTOR GAMMA-CHAIN; IX-V COMPLEX; TYROSINE PHOSPHORYLATION; INTEGRIN ALPHA(IIB)BETA(3);
Keywords:
glycoprotein Ib-IX-V; intracellular signalling; platelet adhesion; von Willebrand factor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, SP Box Hill Hosp, Monash Med Sch, Australian Ctr Blood Dis, Dept Med, Arnold St, Box Hill, Vic 3128, Australia Box Hill Hosp Arnold St Box Hill Vic Australia 3128 Australia
Citazione:
S.M. Dopheide et al., "Dynamic aspects of platelet adhesion under flow", CLIN EXP PH, 28(5-6), 2001, pp. 355-363

Abstract

1. Cell-cell and cell-matrix adhesive interactions are critical for a widerange of physiological processes, including embryogenesis, inflammation, immunity and haemostasis.2. The ability of circulating blood cells, such as platelets and leucocytes, to adhere to sites of vascular injury is complicated by the presence of blood flow, which imposes hydrodynamic forces on adhesion contacts.3. To overcome this problem, platelets and leucocytes have evolved specific adhesion receptors with unique biomechanical properties that enable thesecells to adhere to the vessel wall under flow conditions.4. Platelet adhesion in the normal circulation appears to be a multiple-step process involving an initial reversible interaction between the plateletadhesion receptor glycoprotein Ib-IX-V and the vascular adhesion protein von Willebrand factor. Once tethered to the vessel wall, platelets form irreversible adhesion contacts through the binding of one or more platelet integrins to specific subendothelial matrix proteins.5. There is now a wealth of evidence demonstrating that these receptors not only mediate platelet adhesion, but also transduce signals leading to platelet activation.6. In the present review, we will briefly discuss the current understanding of the specific roles of individual platelet receptors in supporting the haemostatic function of platelets and discuss mechanisms by which these receptors induce platelet activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:30:14