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Titolo:
Neuroprotection in the MPTP parkinsonian C57BL/6 mouse model by a compoundisolated from tobacco
Autore:
Castagnoli, KP; Steyn, SJ; Petzer, JP; Van der Schyf, CJ; Castagnoli, N;
Indirizzi:
Virginia Tech, Dept Chem, Harvey W Peters Ctr, Blacksburg, VA 24061 USA Virginia Tech Blacksburg VA USA 24061 eters Ctr, Blacksburg, VA 24061 USA Virginia Tech, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA Virginia Tech Blacksburg VA USA 24061 Pathobiol, Blacksburg, VA 24061 USA
Titolo Testata:
CHEMICAL RESEARCH IN TOXICOLOGY
fascicolo: 5, volume: 14, anno: 2001,
pagine: 523 - 527
SICI:
0893-228X(200105)14:5<523:NITMPC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-B; CIGARETTE SMOKERS; DOPAMINERGIC NEUROTOXICITY; STRIATAL DOPAMINE; INHIBITION; MICE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 7-NITROINDAZOLE; PROTECTION; SYNTHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Castagnoli, KP Virginia Tech, Dept Chem, Harvey W Peters Ctr, Blacksburg, VA 24061 USA Virginia Tech Blacksburg VA USA 24061 ksburg, VA 24061 USA
Citazione:
K.P. Castagnoli et al., "Neuroprotection in the MPTP parkinsonian C57BL/6 mouse model by a compoundisolated from tobacco", CHEM RES T, 14(5), 2001, pp. 523-527

Abstract

Epidemiological evidence suggests a lower incidence of Parkinson's diseasein smokers than in nonsmokers. This evidence, together with the lower levels of brain monoamine oxidase (MAO) activity in smokers and the potential neuroprotective properties of MAO inhibitors, prompted studies which led to the isolation and characterization of 2,3,6-trimethyl-1,4-naphthsquinone (TMN), an MAO-A and MAO-B inhibitor which is present in tobacco and tobacco smoke. Results of experiments reported here provide evidence that this compound protects against the MPTP-mediated depletion of neostriatal dopamine levels in the C57BL/6 mouse. These results support the hypothesis that the inhibition of MAO by constituents of tobacco smoke may be related to the decreased incidence of Parkinson's disease in smokers.

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Documento generato il 19/01/20 alle ore 12:05:23